Synthesis and anti-inflammatory activity of derivatives of 5-[(2-disubstitutedamino-6-methyl-pyrimidin-4-yl)-sulfanylmethyl]-3H-1,3,4-oxadiazole-2-thiones

Synthesis and results of anti-inflammatory activity in vivo of 5-[(2-disubstitutedamino-6-methyl-pyrimidin-4-yl)-sulfanylmethyl]-3H-1,3,4-oxadiazole-2-thiones and their S-alkyl-, N 3-acyl- and N 3-aminomethyl derivatives are described. All the tested compounds possess anti-inflammatory activity comp...

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Veröffentlicht in:	Farmaco (Società chimica italiana : 1989) 2004-10, Vol.59 (10), p.767-774
Hauptverfasser:	Burbuliene, Milda Malvina, Jakubkiene, Virginija, Mekuskiene, Giedrute, Udrenaite, Emilija, Smicius, Romualdas, Vainilavicius, Povilas
Format:	Artikel
Sprache:	eng
Schlagworte:	3H-1,3,4-oxadiazole-2-thiones Animals Anti-inflammatory activity Anti-Inflammatory Agents - chemical synthesis Anti-Inflammatory Agents - pharmacology Female Male Mice Mice, Inbred BALB C Oxadiazoles - chemical synthesis Oxadiazoles - pharmacology Rats Rats, Wistar Structure-Activity Relationship Thiones - chemical synthesis Thiones - pharmacology
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Zusammenfassung:	Synthesis and results of anti-inflammatory activity in vivo of 5-[(2-disubstitutedamino-6-methyl-pyrimidin-4-yl)-sulfanylmethyl]-3H-1,3,4-oxadiazole-2-thiones and their S-alkyl-, N 3-acyl- and N 3-aminomethyl derivatives are described. All the tested compounds possess anti-inflammatory activity comparable to that of acetylsalicylic acid and some derivatives of 5-[(6-methyl-2-piperidin-1-yl-pyrimidin-4-yl)-sulfanylmethyl]-3H-1,3,4-oxadiazole-2-thione were found to be much more active than ibuprofen.
ISSN:	0014-827X 1879-0569
DOI:	10.1016/j.farmac.2004.05.007