Controlled torque on superparamagnetic beads for functional biosensors

We demonstrate that a rotating magnetic field can be used to apply a controlled torque on superparamagnetic beads which leads to a tunable bead rotation frequency in fluid. Smooth rotation is obtained for field rotation frequencies many orders of magnitude higher than the bead rotation frequency. A...

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Veröffentlicht in:	Biosensors & bioelectronics 2009-03, Vol.24 (7), p.1937-1941
Hauptverfasser:	Janssen, X.J.A., Schellekens, A.J., van Ommering, K., van IJzendoorn, L.J., Prins, M.W.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biosensing Techniques - instrumentation Biosensors Biotechnology Controlled torque Equipment Design Equipment Failure Analysis Functional biosensor Fundamental and applied biological sciences. Psychology Immunomagnetic Separation - instrumentation Immunomagnetic Separation - methods Magnetic moment Magnetics - instrumentation Methods. Procedures. Technologies Micro-Electrical-Mechanical Systems - instrumentation Nanoparticle size distribution Reproducibility of Results Rotation Sensitivity and Specificity Superparamagnetic beads Torque Various methods and equipments
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Beschreibung
Zusammenfassung:	We demonstrate that a rotating magnetic field can be used to apply a controlled torque on superparamagnetic beads which leads to a tunable bead rotation frequency in fluid. Smooth rotation is obtained for field rotation frequencies many orders of magnitude higher than the bead rotation frequency. A quantitative model is developed, based on results from a comprehensive set of experiments at different field strengths and frequencies. At low frequencies (
ISSN:	0956-5663 1873-4235
DOI:	10.1016/j.bios.2008.09.024