Interleukin-4 as a neuromodulatory cytokine: roles and signaling in the nervous system

Although interleukin (IL)-4 is described as a prototypical anti-inflammatory cytokine, in recent years its role as a neuromodulatory cytokine has been extensively discussed. This review highlights the pivotal contributions of IL-4 during the development and normal physiology of neural cells as well...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2009-02, Vol.1153 (1), p.65-75
Hauptverfasser:	Sholl-Franco, Alfred, da Silva, Ana Gabriela Ledo Santos, Adão-Novaes, Juliana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Humans Interleukin-4 - metabolism Nervous System - metabolism Nervous System - pathology Neurotransmitter Agents - metabolism Receptors, Interleukin-4 - metabolism Signal Transduction
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Beschreibung
Zusammenfassung:	Although interleukin (IL)-4 is described as a prototypical anti-inflammatory cytokine, in recent years its role as a neuromodulatory cytokine has been extensively discussed. This review highlights the pivotal contributions of IL-4 during the development and normal physiology of neural cells as well as IL-4 connections with the pathophysiology of degenerative or inflammatory processes observed in the central and peripheral nervous system.
ISSN:	0077-8923 1749-6632
DOI:	10.1111/j.1749-6632.2008.03962.x