3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists

A novel series of potent and selective 3,4-diamino-1,2,5-thiadiazoles were prepared as CXCR2 receptor antagonists. A series of potent and selective 3,4-diamino-1,2,5-thiadiazoles were prepared and found to show excellent binding affinities towards CXCR2 receptor.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-03, Vol.19 (5), p.1434-1437
Hauptverfasser:	Biju, Purakkattle, Taveras, Arthur G., Yu, Younong, Zheng, Junying, Hipkin, R. William, Fossetta, James, Fan, Xuedong, Fine, Jay, Lundell, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Diamino-1,2,5-thiadiazoles CXCR2 receptor antagonist Diamines - chemical synthesis Diamines - pharmacology Humans Protein Binding Receptors, Interleukin-8B - antagonists & inhibitors Receptors, Interleukin-8B - metabolism Structure-Activity Relationship Thiadiazoles - chemical synthesis Thiadiazoles - pharmacology
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Beschreibung
Zusammenfassung:	A novel series of potent and selective 3,4-diamino-1,2,5-thiadiazoles were prepared as CXCR2 receptor antagonists. A series of potent and selective 3,4-diamino-1,2,5-thiadiazoles were prepared and found to show excellent binding affinities towards CXCR2 receptor.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2009.01.027