Individual effect-site concentrations of propofol at return of consciousness are related to the concentrations at loss of consciousness and age in neurosurgical patients
Abstract Study Objective To investigate whether a patient's propofol effect-site concentration at return to consciousness (ROC) was related to the propofol effect-site concentration at loss of consciousness (LOC) and to patients' individual demographic parameters. Design Prospective study....
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| Veröffentlicht in: | Journal of clinical anesthesia 2009-02, Vol.21 (1), p.3-8 |
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| creator | Nunes, Catarina S Ferreira, David A Antunes, Luís Lobo, Francisco Santos, Isabel A Amorim, Pedro |
| description | Abstract Study Objective To investigate whether a patient's propofol effect-site concentration at return to consciousness (ROC) was related to the propofol effect-site concentration at loss of consciousness (LOC) and to patients' individual demographic parameters. Design Prospective study. Setting Operating room. Patients 31 ASA physical status I and II neurosurgical patients with Glasgow Coma Score > 15, and scheduled to receive total intravenous anesthesia with effect-site target controlled infusion (TCI) of propofol and remifentanil. Interventions A constant propofol infusion was administered until LOC. At LOC, remifentanil started with a plasma concentration target of 2.5 ng mL−1. Main Results Propofol concentration at LOC was 4.9 ± 1 μ g mL−1 . At ROC, propofol and remifentanil concentrations were 1.16 ± 0.3 μ g mL−1 and 3.41 ± 1.5 ng mL−1 . Significant correlation was observed between propofol concentrationa at ROC and LOC, between propofol concentration at ROC and patient age (48.7 ± 15 yrs), and between propofol concentrations at ROC and LOC, divided by patient's age. Conclusions The correlation between propofol concentrations at ROC and LOC was improved by inclusion of patient age data. |
| doi_str_mv | 10.1016/j.jclinane.2008.06.011 |
| format | Article |
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Design Prospective study. Setting Operating room. Patients 31 ASA physical status I and II neurosurgical patients with Glasgow Coma Score > 15, and scheduled to receive total intravenous anesthesia with effect-site target controlled infusion (TCI) of propofol and remifentanil. Interventions A constant propofol infusion was administered until LOC. At LOC, remifentanil started with a plasma concentration target of 2.5 ng mL−1. Main Results Propofol concentration at LOC was 4.9 ± 1 μ g mL−1 . At ROC, propofol and remifentanil concentrations were 1.16 ± 0.3 μ g mL−1 and 3.41 ± 1.5 ng mL−1 . Significant correlation was observed between propofol concentrationa at ROC and LOC, between propofol concentration at ROC and patient age (48.7 ± 15 yrs), and between propofol concentrations at ROC and LOC, divided by patient's age. Conclusions The correlation between propofol concentrations at ROC and LOC was improved by inclusion of patient age data.</description><identifier>ISSN: 0952-8180</identifier><identifier>EISSN: 1873-4529</identifier><identifier>DOI: 10.1016/j.jclinane.2008.06.011</identifier><identifier>PMID: 19232933</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Age Factors ; Aged ; Analgesics ; Anesthesia ; Anesthesia & Perioperative Care ; Anesthesia Recovery Period ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anesthetics, Intravenous - pharmacokinetics ; Anesthetics, Intravenous - therapeutic use ; Biological and medical sciences ; Consciousness ; Consciousness - drug effects ; Consciousness, loss of ; Consciousness, return to ; Drug dosages: effect-site concentrations ; Drug Therapy, Combination ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Neurosurgical Procedures - methods ; Pain Medicine ; Piperidines - pharmacokinetics ; Piperidines - therapeutic use ; Plasma ; Propofol - pharmacokinetics ; Propofol - therapeutic use ; Propofol, hypnotic dose ; Prospective Studies ; Surgery ; Young Adult</subject><ispartof>Journal of clinical anesthesia, 2009-02, Vol.21 (1), p.3-8</ispartof><rights>Elsevier Inc.</rights><rights>2009 Elsevier Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-4dc0fae9456227062eff9f2333f2bd5184808accdf474c52c843d6ac6e8cc93c3</citedby><cites>FETCH-LOGICAL-c507t-4dc0fae9456227062eff9f2333f2bd5184808accdf474c52c843d6ac6e8cc93c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1034980497?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994,64384,64386,64388,72240</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21200617$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19232933$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nunes, Catarina S</creatorcontrib><creatorcontrib>Ferreira, David A</creatorcontrib><creatorcontrib>Antunes, Luís</creatorcontrib><creatorcontrib>Lobo, Francisco</creatorcontrib><creatorcontrib>Santos, Isabel A</creatorcontrib><creatorcontrib>Amorim, Pedro</creatorcontrib><title>Individual effect-site concentrations of propofol at return of consciousness are related to the concentrations at loss of consciousness and age in neurosurgical patients</title><title>Journal of clinical anesthesia</title><addtitle>J Clin Anesth</addtitle><description>Abstract Study Objective To investigate whether a patient's propofol effect-site concentration at return to consciousness (ROC) was related to the propofol effect-site concentration at loss of consciousness (LOC) and to patients' individual demographic parameters. Design Prospective study. Setting Operating room. Patients 31 ASA physical status I and II neurosurgical patients with Glasgow Coma Score > 15, and scheduled to receive total intravenous anesthesia with effect-site target controlled infusion (TCI) of propofol and remifentanil. Interventions A constant propofol infusion was administered until LOC. At LOC, remifentanil started with a plasma concentration target of 2.5 ng mL−1. Main Results Propofol concentration at LOC was 4.9 ± 1 μ g mL−1 . At ROC, propofol and remifentanil concentrations were 1.16 ± 0.3 μ g mL−1 and 3.41 ± 1.5 ng mL−1 . Significant correlation was observed between propofol concentrationa at ROC and LOC, between propofol concentration at ROC and patient age (48.7 ± 15 yrs), and between propofol concentrations at ROC and LOC, divided by patient's age. Conclusions The correlation between propofol concentrations at ROC and LOC was improved by inclusion of patient age data.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Analgesics</subject><subject>Anesthesia</subject><subject>Anesthesia & Perioperative Care</subject><subject>Anesthesia Recovery Period</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anesthetics, Intravenous - pharmacokinetics</subject><subject>Anesthetics, Intravenous - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Consciousness</subject><subject>Consciousness - drug effects</subject><subject>Consciousness, loss of</subject><subject>Consciousness, return to</subject><subject>Drug dosages: effect-site concentrations</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurosurgical Procedures - methods</subject><subject>Pain Medicine</subject><subject>Piperidines - pharmacokinetics</subject><subject>Piperidines - therapeutic use</subject><subject>Plasma</subject><subject>Propofol - pharmacokinetics</subject><subject>Propofol - therapeutic use</subject><subject>Propofol, hypnotic dose</subject><subject>Prospective Studies</subject><subject>Surgery</subject><subject>Young Adult</subject><issn>0952-8180</issn><issn>1873-4529</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkl-L1DAUxYso7rj6FZaA6FvrTdKm7Ysoi38WFnxQn0M2uV0zdpIxSRf2I_ktvWVGF1ZBKASa3z2ce06q6oxDw4GrV9tma2cfTMBGAAwNqAY4f1Bt-NDLuu3E-LDawNiJeuADnFRPct4CAF3wx9UJH4UUo5Sb6udFcP7Gu8XMDKcJbamzL8hsDBZDSab4GDKLE9unuI9TnJkpLGFZUlj_Epetj0sOmDMzCeluNgUdK5GVb38J0fAcc_7HaHDMXCPzgQVcUsxLuvaWXO1pkgTy0-rRZOaMz47nafX1_bsv5x_ry08fLs7fXta2g77UrbMwGRzbTgnRgxK01TgJKeUkrlzHh3aAwVjrprZvbSfs0EqnjFU4WDtKK0-rlwddWvjHgrnonc8W55myJrNaqbHtBfQEPr8HbiOlQt40B9mOA7TjSqkDZWmnnHDS--R3Jt0SpNcq9Vb_rlKvVWpQmqqkwbOj_HK1Q3c3duyOgBdHwGQKakomWJ__cIKTmuKrgzcHDim1G49JU-xIrTifqG_tov-_l9f3JFZqrec73mK-21tnoUF_Xh_e-u6APjECyF96JtlQ</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Nunes, Catarina S</creator><creator>Ferreira, David A</creator><creator>Antunes, Luís</creator><creator>Lobo, Francisco</creator><creator>Santos, Isabel A</creator><creator>Amorim, Pedro</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20090201</creationdate><title>Individual effect-site concentrations of propofol at return of consciousness are related to the concentrations at loss of consciousness and age in neurosurgical patients</title><author>Nunes, Catarina S ; Ferreira, David A ; Antunes, Luís ; Lobo, Francisco ; Santos, Isabel A ; Amorim, Pedro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-4dc0fae9456227062eff9f2333f2bd5184808accdf474c52c843d6ac6e8cc93c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Analgesics</topic><topic>Anesthesia</topic><topic>Anesthesia & Perioperative Care</topic><topic>Anesthesia Recovery Period</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anesthetics, Intravenous - pharmacokinetics</topic><topic>Anesthetics, Intravenous - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Consciousness</topic><topic>Consciousness - drug effects</topic><topic>Consciousness, loss of</topic><topic>Consciousness, return to</topic><topic>Drug dosages: effect-site concentrations</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurosurgical Procedures - methods</topic><topic>Pain Medicine</topic><topic>Piperidines - pharmacokinetics</topic><topic>Piperidines - therapeutic use</topic><topic>Plasma</topic><topic>Propofol - pharmacokinetics</topic><topic>Propofol - therapeutic use</topic><topic>Propofol, hypnotic dose</topic><topic>Prospective Studies</topic><topic>Surgery</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nunes, Catarina S</creatorcontrib><creatorcontrib>Ferreira, David A</creatorcontrib><creatorcontrib>Antunes, Luís</creatorcontrib><creatorcontrib>Lobo, Francisco</creatorcontrib><creatorcontrib>Santos, Isabel A</creatorcontrib><creatorcontrib>Amorim, Pedro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nunes, Catarina S</au><au>Ferreira, David A</au><au>Antunes, Luís</au><au>Lobo, Francisco</au><au>Santos, Isabel A</au><au>Amorim, Pedro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Individual effect-site concentrations of propofol at return of consciousness are related to the concentrations at loss of consciousness and age in neurosurgical patients</atitle><jtitle>Journal of clinical anesthesia</jtitle><addtitle>J Clin Anesth</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>21</volume><issue>1</issue><spage>3</spage><epage>8</epage><pages>3-8</pages><issn>0952-8180</issn><eissn>1873-4529</eissn><abstract>Abstract Study Objective To investigate whether a patient's propofol effect-site concentration at return to consciousness (ROC) was related to the propofol effect-site concentration at loss of consciousness (LOC) and to patients' individual demographic parameters. Design Prospective study. Setting Operating room. Patients 31 ASA physical status I and II neurosurgical patients with Glasgow Coma Score > 15, and scheduled to receive total intravenous anesthesia with effect-site target controlled infusion (TCI) of propofol and remifentanil. Interventions A constant propofol infusion was administered until LOC. At LOC, remifentanil started with a plasma concentration target of 2.5 ng mL−1. Main Results Propofol concentration at LOC was 4.9 ± 1 μ g mL−1 . At ROC, propofol and remifentanil concentrations were 1.16 ± 0.3 μ g mL−1 and 3.41 ± 1.5 ng mL−1 . Significant correlation was observed between propofol concentrationa at ROC and LOC, between propofol concentration at ROC and patient age (48.7 ± 15 yrs), and between propofol concentrations at ROC and LOC, divided by patient's age. Conclusions The correlation between propofol concentrations at ROC and LOC was improved by inclusion of patient age data.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>19232933</pmid><doi>10.1016/j.jclinane.2008.06.011</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Factors Aged Analgesics Anesthesia Anesthesia & Perioperative Care Anesthesia Recovery Period Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics, Intravenous - pharmacokinetics Anesthetics, Intravenous - therapeutic use Biological and medical sciences Consciousness Consciousness - drug effects Consciousness, loss of Consciousness, return to Drug dosages: effect-site concentrations Drug Therapy, Combination Female Humans Male Medical sciences Middle Aged Neurosurgical Procedures - methods Pain Medicine Piperidines - pharmacokinetics Piperidines - therapeutic use Plasma Propofol - pharmacokinetics Propofol - therapeutic use Propofol, hypnotic dose Prospective Studies Surgery Young Adult |
| title | Individual effect-site concentrations of propofol at return of consciousness are related to the concentrations at loss of consciousness and age in neurosurgical patients |
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