Hyperbaric oxygen therapy in BKV-associated hemorrhagic cystitis refractory to intravenous and intravesical cidofovir: Case report and review of literature

Abstract Hemorrhagic cystitis is a common complication in hematopoietic stem cell transplant recipients. We report here a case of severe BKV-associated hemorrhagic cystitis who did not respond to intravenous cidofovir. Overt hematuria successfully resolved after a few days on hyperbaric oxygen and i...

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Veröffentlicht in:Leukemia research 2009-04, Vol.33 (4), p.556-560
Hauptverfasser: Focosi, Daniele, Maggi, Fabrizio, Pistolesi, Donatella, Benedetti, Edoardo, Papineschi, Federico, Galimberti, Sara, Ceccherini-Nelli, Luca, Petrini, Mario
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Sprache:eng
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Zusammenfassung:Abstract Hemorrhagic cystitis is a common complication in hematopoietic stem cell transplant recipients. We report here a case of severe BKV-associated hemorrhagic cystitis who did not respond to intravenous cidofovir. Overt hematuria successfully resolved after a few days on hyperbaric oxygen and intravesical instillations of cidofovir, while BK viruria dropped after a few weeks and remained low. We review the literature for therapeutic options in hemorrhagic cystitis and try to explain how hyperbaric oxygen stimulates mucosal repair in the urinary bladder.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2008.06.018