Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients

Experimental and clinical studies give evidence for breakdown of membrane phospholipids during neurodegeneration. In the present study, we measured the levels of glycerophosphocholine (GPCh), phosphocholine (PCh), and choline, that is, water-soluble metabolites of phosphatidylcholine (PtdCho), in human cerebrospinal fluid (CSF). Among 30 cognitively normal patients the average CSF levels of GPCh, phosphocholine and choline were 3.64, 1.28, and 1.93 μM, respectively; metabolite levels did not change with increasing age. When compared with age-matched controls, patients with Alzheimer’s disease had elevated levels of all choline metabolites: GPCh was significantly increased by 76% ( P