Peroxisome proliferator-activated receptor γ: Its role in metabolic syndrome

Here we review PPARγ function in relation to human adipogenesis, insulin sensitization, lipid metabolism, blood pressure regulation and prothrombotic state to perhaps provide justification for this nuclear receptor remaining a key therapeutic target for the continuing development of agents to treat...

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Veröffentlicht in:	Cardiovascular Radiation Medicine 2004-04, Vol.5 (2), p.97-103
Hauptverfasser:	Pakala, Rajbabu, Kuchulakanti, Pramod, Rha, Seung-Woon, Cheneau, Edouard, Baffour, Richard, Waksman, Ron
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism Anti-Inflammatory Agents, Non-Steroidal - pharmacology Diabetes mellitus Humans Hyperlipidemias - metabolism Hypertension - metabolism Hypoglycemic Agents - pharmacology Inflammation - metabolism Insulin Resistance - physiology Metabolic syndrome Metabolic Syndrome - drug therapy Metabolic Syndrome - metabolism PPAR gamma - drug effects PPAR gamma - physiology Prothrombin - metabolism
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Beschreibung
Zusammenfassung:	Here we review PPARγ function in relation to human adipogenesis, insulin sensitization, lipid metabolism, blood pressure regulation and prothrombotic state to perhaps provide justification for this nuclear receptor remaining a key therapeutic target for the continuing development of agents to treat human metabolic syndrome.
ISSN:	1522-1865
DOI:	10.1016/j.carrad.2004.03.006