PNIPAM Gel-Coated Gold Nanorods for Targeted Delivery Responding to a Near-Infrared Laser

PNIPAM Gel-Coated Gold Nanorods for Targeted Delivery Responding to a Near-Infrared Laser

Gold nanorods can be used as photothermal converters, permitting near-infrared (NIR) light to be transmitted deep into tissues without causing damage. We prepared hybrid nanorods with a core−shell structure, i.e., a single gold nanorod encapsulated in a poly (N-isopropylacrylamide) nanogel. Hybrid n...

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Veröffentlicht in:Bioconjugate chemistry 2009-02, Vol.20 (2), p.209-212
Hauptverfasser: Kawano, Takahito, Niidome, Yasuro, Mori, Takeshi, Katayama, Yoshiki, Niidome, Takuro
Format: Artikel
Sprache:eng
Schlagworte:
Acrylamides - chemistry
Acrylic Resins - chemistry
Animals
Cross-Linking Reagents - chemistry
Drug Carriers - chemistry
Drug Carriers - metabolism
Gels
Gold
Gold - chemistry
Infrared radiation
Infrared Rays
Lasers
Mice
Nanotubes - chemistry
Phase transitions
Polymers - chemistry
Temperature
Tissues
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Zusammenfassung:Gold nanorods can be used as photothermal converters, permitting near-infrared (NIR) light to be transmitted deep into tissues without causing damage. We prepared hybrid nanorods with a core−shell structure, i.e., a single gold nanorod encapsulated in a poly (N-isopropylacrylamide) nanogel. Hybrid nanorods demonstrated remote, reversible, pulsatile phase transition and in vivo action after irradiation using a NIR laser.
ISSN:1043-1802
1520-4812
DOI:10.1021/bc800480k