Melanogenesis Stimulation in Murine B16 Melanoma Cells by Piper nigrum Leaf Extract and Its Lignan Constituents

A methanolic extract from the leaves of Piper nigrum L. showed a significant stimulatory effect on melanogenesis in cultured murine B16 melanoma cells. Activity-guided fractionation of the methanolic extract led to the isolation of two known lignans, (−)-cubebin (1) and (−)-3,4-dimethoxy-3,4-desmeth...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2004, Vol.27(10), pp.1611-1616
Hauptverfasser:	Matsuda, Hideaki, Kawaguchi, Yoshiko, Yamazaki, Miho, Hirata, Noriko, Naruto, Shunsuke, Asanuma, Yusuke, Kaihatsu, Takayuki, Kubo, Michinori
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-dimethoxy-3,4-desmethylenedioxycubebin 3-desmethoxycubebinin Animals Cell Proliferation - drug effects cubebin Lignans - chemistry Lignans - isolation & purification Lignans - pharmacology Melanins - biosynthesis Melanoma, Experimental Mice murine B16 melanoma cell Piper nigrum Plant Extracts - chemistry Plant Extracts - pharmacology Plant Leaves stimulatory effect on melanogenesis Tumor Cells, Cultured
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Zusammenfassung:	A methanolic extract from the leaves of Piper nigrum L. showed a significant stimulatory effect on melanogenesis in cultured murine B16 melanoma cells. Activity-guided fractionation of the methanolic extract led to the isolation of two known lignans, (−)-cubebin (1) and (−)-3,4-dimethoxy-3,4-desmethylenedioxycubebin (2), together with a new lignan, (−)-3-desmethoxycubebinin (3). Among these lignans, 1 and 2 showed a significant stimulatory activity of melanogenesis without any significant effects on cell proliferation.
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.27.1611