Receptor-Mediated Targeting of Cathepsins in Professional Antigen Presenting Cells
Tag for professionals: A fluorescently tagged clustered mannoside DCG-04 analogue (see structure) is designed and synthesized using a modular approach. Uptake of the probe in professional antigen presenting cells and subsequent labeling of cathepsins proceeded in a mannose-receptor dependent manner.
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| Veröffentlicht in: | Angewandte Chemie (International ed.) 2009-02, Vol.48 (9), p.1629-1632 |
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| container_end_page | 1632 |
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| container_issue | 9 |
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| container_title | Angewandte Chemie (International ed.) |
| container_volume | 48 |
| creator | Hillaert, Ulrik Verdoes, Martijn Florea, Bogdan I Saragliadis, Anastasios Habets, Kim L.L Kuiper, Johan Van Calenbergh, Serge Ossendorp, Ferry van der Marel, Gijsbert A Driessen, Christoph Overkleeft, Hermen S |
| description | Tag for professionals: A fluorescently tagged clustered mannoside DCG-04 analogue (see structure) is designed and synthesized using a modular approach. Uptake of the probe in professional antigen presenting cells and subsequent labeling of cathepsins proceeded in a mannose-receptor dependent manner. |
| doi_str_mv | 10.1002/anie.200805529 |
| format | Article |
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Uptake of the probe in professional antigen presenting cells and subsequent labeling of cathepsins proceeded in a mannose-receptor dependent manner.</description><subject>Animals</subject><subject>Antigen-Presenting Cells - immunology</subject><subject>Cathepsins - metabolism</subject><subject>Cells, Cultured</subject><subject>cycloaddition</subject><subject>enzyme inhibitors</subject><subject>hydrolases</subject><subject>Lectins, C-Type - metabolism</subject><subject>Leucine - analogs & derivatives</subject><subject>Leucine - chemical synthesis</subject><subject>Leucine - chemistry</subject><subject>Leucine - pharmacology</subject><subject>Mannose-Binding Lectins - metabolism</subject><subject>mannoside</subject><subject>proteomics</subject><subject>Rats</subject><subject>Receptors, Cell Surface - metabolism</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1v2zAQhokgRZymXTMmmrrJPZIiKY6GYecDbhq4MToSpHRy2MqSQ8po8u8rV0bSLdMdDs_74vAQck5hTAHYV9t4HDOAHIRg-oicUsFoypXix_2ecZ6qXNAR-Rjjr57Pc5AnZEQ1FVLlcEqWSyxw27Uh_Yaltx2WyYMNa-x8s07aKpna7hG30Tcx8U1yH9oKY_RtY-tk0nR-jfsjRmz-BaZY1_ET-VDZOuLnwzwjq_nsYXqdLr5f3Uwni7QQwHSaSa6cEjyDUuUUi4qDEgiZc64otdYKhC0ck4DCWklBSyVdWThXWsdK5fgZ-TL0bkP7tMPYmY2PRf-BbbDdRSOl5pkS4l2QQcYzLlQPjgewCG2MASuzDX5jw4uhYPa6zV63edXdBy4OzTu3wfINP_jtAT0Af3yNL-_Umcndzez_8nTI-tjh82vWht9GKq6E-Xl3ZeT9MpvfLpi57fnLga9sa-w6-GhWPxhQDlRoqXvVfwGeh6TS</recordid><startdate>20090216</startdate><enddate>20090216</enddate><creator>Hillaert, Ulrik</creator><creator>Verdoes, Martijn</creator><creator>Florea, Bogdan I</creator><creator>Saragliadis, Anastasios</creator><creator>Habets, Kim L.L</creator><creator>Kuiper, Johan</creator><creator>Van Calenbergh, Serge</creator><creator>Ossendorp, Ferry</creator><creator>van der Marel, Gijsbert A</creator><creator>Driessen, Christoph</creator><creator>Overkleeft, Hermen S</creator><general>Wiley-VCH Verlag</general><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20090216</creationdate><title>Receptor-Mediated Targeting of Cathepsins in Professional Antigen Presenting Cells</title><author>Hillaert, Ulrik ; Verdoes, Martijn ; Florea, Bogdan I ; Saragliadis, Anastasios ; Habets, Kim L.L ; Kuiper, Johan ; Van Calenbergh, Serge ; Ossendorp, Ferry ; van der Marel, Gijsbert A ; Driessen, Christoph ; Overkleeft, Hermen S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5029-4637b75340d781ecf3075e04bbbcd999705acb260e5aa6109676bdcbbdab2d7b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Antigen-Presenting Cells - immunology</topic><topic>Cathepsins - metabolism</topic><topic>Cells, Cultured</topic><topic>cycloaddition</topic><topic>enzyme inhibitors</topic><topic>hydrolases</topic><topic>Lectins, C-Type - metabolism</topic><topic>Leucine - analogs & derivatives</topic><topic>Leucine - chemical synthesis</topic><topic>Leucine - chemistry</topic><topic>Leucine - pharmacology</topic><topic>Mannose-Binding Lectins - metabolism</topic><topic>mannoside</topic><topic>proteomics</topic><topic>Rats</topic><topic>Receptors, Cell Surface - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hillaert, Ulrik</creatorcontrib><creatorcontrib>Verdoes, Martijn</creatorcontrib><creatorcontrib>Florea, Bogdan I</creatorcontrib><creatorcontrib>Saragliadis, Anastasios</creatorcontrib><creatorcontrib>Habets, Kim L.L</creatorcontrib><creatorcontrib>Kuiper, Johan</creatorcontrib><creatorcontrib>Van Calenbergh, Serge</creatorcontrib><creatorcontrib>Ossendorp, Ferry</creatorcontrib><creatorcontrib>van der Marel, Gijsbert A</creatorcontrib><creatorcontrib>Driessen, Christoph</creatorcontrib><creatorcontrib>Overkleeft, Hermen S</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Angewandte Chemie (International ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hillaert, Ulrik</au><au>Verdoes, Martijn</au><au>Florea, Bogdan I</au><au>Saragliadis, Anastasios</au><au>Habets, Kim L.L</au><au>Kuiper, Johan</au><au>Van Calenbergh, Serge</au><au>Ossendorp, Ferry</au><au>van der Marel, Gijsbert A</au><au>Driessen, Christoph</au><au>Overkleeft, Hermen S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Receptor-Mediated Targeting of Cathepsins in Professional Antigen Presenting Cells</atitle><jtitle>Angewandte Chemie (International ed.)</jtitle><addtitle>Angewandte Chemie International Edition</addtitle><date>2009-02-16</date><risdate>2009</risdate><volume>48</volume><issue>9</issue><spage>1629</spage><epage>1632</epage><pages>1629-1632</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><abstract>Tag for professionals: A fluorescently tagged clustered mannoside DCG-04 analogue (see structure) is designed and synthesized using a modular approach. 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| fulltext | fulltext |
| identifier | ISSN: 1433-7851 |
| ispartof | Angewandte Chemie (International ed.), 2009-02, Vol.48 (9), p.1629-1632 |
| issn | 1433-7851 1521-3773 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Antigen-Presenting Cells - immunology Cathepsins - metabolism Cells, Cultured cycloaddition enzyme inhibitors hydrolases Lectins, C-Type - metabolism Leucine - analogs & derivatives Leucine - chemical synthesis Leucine - chemistry Leucine - pharmacology Mannose-Binding Lectins - metabolism mannoside proteomics Rats Receptors, Cell Surface - metabolism |
| title | Receptor-Mediated Targeting of Cathepsins in Professional Antigen Presenting Cells |
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