Receptor-Mediated Targeting of Cathepsins in Professional Antigen Presenting Cells

Tag for professionals: A fluorescently tagged clustered mannoside DCG-04 analogue (see structure) is designed and synthesized using a modular approach. Uptake of the probe in professional antigen presenting cells and subsequent labeling of cathepsins proceeded in a mannose-receptor dependent manner.

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Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie (International ed.) 2009-02, Vol.48 (9), p.1629-1632
Hauptverfasser:	Hillaert, Ulrik, Verdoes, Martijn, Florea, Bogdan I, Saragliadis, Anastasios, Habets, Kim L.L, Kuiper, Johan, Van Calenbergh, Serge, Ossendorp, Ferry, van der Marel, Gijsbert A, Driessen, Christoph, Overkleeft, Hermen S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen-Presenting Cells - immunology Cathepsins - metabolism Cells, Cultured cycloaddition enzyme inhibitors hydrolases Lectins, C-Type - metabolism Leucine - analogs & derivatives Leucine - chemical synthesis Leucine - chemistry Leucine - pharmacology Mannose-Binding Lectins - metabolism mannoside proteomics Rats Receptors, Cell Surface - metabolism
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Beschreibung
Zusammenfassung:	Tag for professionals: A fluorescently tagged clustered mannoside DCG-04 analogue (see structure) is designed and synthesized using a modular approach. Uptake of the probe in professional antigen presenting cells and subsequent labeling of cathepsins proceeded in a mannose-receptor dependent manner.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200805529