A New Lignan Glycoside and Phenylethanoid Glycosides from Strobilanthes cusia BREMEK

The root of Strobilanthes cusia BREMEK. (Acanthaceae), popularly known as Da-Ching-Yeh, has been commonly used in traditional Chinese medicine. It is used to treat influenza, epidemic cerebrospinal meningitis, encephalitis B, viral pneumonia, mumps, and severe acute respiratory syndrome (SARS). In t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2004, Vol.52(10), pp.1242-1245
Hauptverfasser:	Tanaka, Tomonori, Ikeda, Tsuyoshi, Kaku, Miho, Zhu, Xing-Hua, Okawa, Masafumi, Yokomizo, Kazumi, Uyeda, Masaru, Nohara, Toshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Acanthaceae Animals anti-herpes simplex virus type-1 activity Antiviral Agents - chemistry Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Cercopithecus aethiops Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - pharmacology Glycosides - chemistry Glycosides - isolation & purification Glycosides - pharmacology Herpesvirus 1, Human - drug effects lignan Lignans - chemistry Lignans - isolation & purification Lignans - pharmacology Magnetic Resonance Spectroscopy phenylethanoid Phenylpropionates - chemistry Phenylpropionates - isolation & purification Phenylpropionates - pharmacology Plant Roots Stereoisomerism Strobilanthes cusia Vero Cells
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The root of Strobilanthes cusia BREMEK. (Acanthaceae), popularly known as Da-Ching-Yeh, has been commonly used in traditional Chinese medicine. It is used to treat influenza, epidemic cerebrospinal meningitis, encephalitis B, viral pneumonia, mumps, and severe acute respiratory syndrome (SARS). In this study, we found a new lignan glycoside (6) and two new phenylethanoid glycosides (7, 8) together with five known compounds as chemical constituents of Strobilanthes cusia root. Some samples were examined for anti-herpes simplex virus type-1 (HSV-1) activity. Among the tested samples, lupeol showed anti-HSV-1 activity (EC50: 11.7 μM) and showed 100% inhibition of virus plaque formation at 58.7 μM.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.52.1242