Triterpenoids from Acanthopanax koreanum root and their inhibitory activities on NFAT transcription

Two triterpenoids (1,4) and two triterpenoid glycosides (2,3) were isolated from the root of Acanthopanax koreanum (Araliaceae). Their structures were identified as impressic acid (1), acankoreoside A (2), 3-epi-betulinic acid 28-O-[alpha-L-rhamnopyranosyl(1 --> 4)-beta-D-glucopyranosyl(1 -->...

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Veröffentlicht in:	Archives of pharmacal research 2004-08, Vol.27 (8), p.825-828
Hauptverfasser:	Cai, Xing Fu, Lee, Im Seon, Shen, Guanghai, Dat, Nguyen Tien, Lee, Jung Joon, Kim, Young Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - metabolism Eleutherococcus NFATC Transcription Factors Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - metabolism Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Roots Transcription Factors - antagonists & inhibitors Transcription Factors - metabolism Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology
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Beschreibung
Zusammenfassung:	Two triterpenoids (1,4) and two triterpenoid glycosides (2,3) were isolated from the root of Acanthopanax koreanum (Araliaceae). Their structures were identified as impressic acid (1), acankoreoside A (2), 3-epi-betulinic acid 28-O-[alpha-L-rhamnopyranosyl(1 --> 4)-beta-D-glucopyranosyl(1 --> 6)]-beta-D-glucopyranosyl] ester (3), and ursolic acid (4) by physicochemical and spectroscopic methods. Of these compounds, impressic acid (1) exhibited a potent inhibitory activity against NFAT transcription factor (IC50: 12.65 microM).
ISSN:	0253-6269
DOI:	10.1007/BF02980173