Recombinant human factor VIIa (rFVIIa) can activate factor FIX on activated platelets

The studies reported here show that factor (F)VIIa can activate factor (F)IX on activated platelets in the absence of tissue factor. Both FIX and FIXa bind to the activated platelet surface with a Kd of 8 nM and 2 nM, respectively. With factor (F)VIIIa, FIXa binds more tightly to platelets (Kd 0.6 n...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2004-10, Vol.2 (10), p.1816-1822
Hauptverfasser:	Gabriel, D. A., Li, X., Monroe, D. M., Roberts, H. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Coagulation - drug effects Blood Platelets - drug effects Blood Platelets - metabolism Cysteine Endopeptidases - biosynthesis factor FVIIa factor IX Factor IX - metabolism Factor IXa - metabolism Factor VII - pharmacology Factor VIIa Humans light scattering Neoplasm Proteins - biosynthesis platelet Platelet Activation Recombinant Proteins - pharmacology Thrombin - biosynthesis Thromboplastin
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Beschreibung
Zusammenfassung:	The studies reported here show that factor (F)VIIa can activate factor (F)IX on activated platelets in the absence of tissue factor. Both FIX and FIXa bind to the activated platelet surface with a Kd of 8 nM and 2 nM, respectively. With factor (F)VIIIa, FIXa binds more tightly to platelets (Kd 0.6 nM). At rFVIIa concentrations
ISSN:	1538-7933 1538-7836 1538-7836
DOI:	10.1111/j.1538-7836.2004.01015.x