3-Methoxytyramine as an indicator of dopaminergic manipulation in the equine athlete

The influence of sampling variables on the concentration of the dopamine metabolites 3-methoxytyramine (3MT), dihydroxyphenylacetic acid (DOPAC) and homovanilic acid (HVA) was examined in equine urine. A logarithmic transformation of the data for all horses gave distribution which approximated the n...

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Veröffentlicht in:	Journal of chromatography. B 2004-11, Vol.811 (1), p.93-101
Hauptverfasser:	WYNNE, Paul M, VINE, John H, AMIET, R. Gary
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Dopamine - administration & dosage Dopamine - analogs & derivatives Dopamine - urine Doping in Sports Fundamental and applied biological sciences. Psychology General pharmacology Horses Medical sciences Pharmacology. Drug treatments
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Zusammenfassung:	The influence of sampling variables on the concentration of the dopamine metabolites 3-methoxytyramine (3MT), dihydroxyphenylacetic acid (DOPAC) and homovanilic acid (HVA) was examined in equine urine. A logarithmic transformation of the data for all horses gave distribution which approximated the normal distributions for each metabolite. The mean urinary concentration of 3 MT in horses was 214 ng/mL and the application of a threshold with a probability of 1 in 10,000 gave an actionable level of 4 microg/mL. Environmental variables were not forensically significant in determining the population distribution. HVA was not found to be a reliable indicator of dopamine or levodopa administration.
ISSN:	1570-0232 1873-376X
DOI:	10.1016/S1570-0232(04)00632-4