Effect of lupus anticoagulant on the interaction of prothrombin with platelets

Effect of lupus anticoagulant on the interaction of prothrombin with platelets

We studied binding of (125)I-labeled prothrombin to platelets in the presence of circulating endogenous lupus anticoagulant. Lupus anticoagulant modulated the interaction and increased affinity of prothrombin for calcium-independent binding sites on platelets. The number of these sites decreased, wh...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2004-06, Vol.137 (6), p.538-540
Hauptverfasser: Kiselev, S V, Zubairov, D M, Andrushko, I A, Katsadze, Yu L
Format: Artikel
Sprache:eng
Schlagworte:
Binding Sites
Blood Platelets - metabolism
Calcium - metabolism
Humans
Iodine Radioisotopes - metabolism
Lupus Coagulation Inhibitor - metabolism
Protein Binding
Prothrombin - chemistry
Prothrombin - metabolism
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Zusammenfassung:We studied binding of (125)I-labeled prothrombin to platelets in the presence of circulating endogenous lupus anticoagulant. Lupus anticoagulant modulated the interaction and increased affinity of prothrombin for calcium-independent binding sites on platelets. The number of these sites decreased, while the total number of calcium-dependent binding sites increased. Our results indicate that lupus anticoagulant plays a role in the binding of prothrombin to nonactivated platelets.
ISSN:0007-4888
1573-8221
DOI:10.1023/B:BEBM.0000042705.59356.05