5-Amidinoindoles as dual inhibitors of coagulation factors IXa and Xa

Structural features of a 5-amidinoindole inhibitor of factor Xa, which displayed modest inhibition of factor IXa were varied to increase potency and improve selectivity for factor IXa.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2004-11, Vol.14 (21), p.5269-5273
Hauptverfasser:	Batt, Douglas G, Qiao, Jennifer X, Modi, Dilip P, Houghton, Gregory C, Pierson, Deborah A, Rossi, Karen A, Luettgen, Joseph M, Knabb, Robert M, Jadhav, P K, Wexler, Ruth R
Format:	Artikel
Sprache:	eng
Schlagworte:	Factor IXa - antagonists & inhibitors Factor IXa - chemistry Factor Xa - chemistry Factor Xa Inhibitors Indoles - chemical synthesis Indoles - chemistry Models, Molecular Stereoisomerism Structure-Activity Relationship Substrate Specificity
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Structural features of a 5-amidinoindole inhibitor of factor Xa, which displayed modest inhibition of factor IXa were varied to increase potency and improve selectivity for factor IXa.
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2004.08.037