Aerosolisation of beclomethasone dipropionate using spray dried lactose/polyethylene glycol carriers

Aerosolisation of beclomethasone dipropionate using spray dried lactose/polyethylene glycol carriers

The aim of this study was to characterize the physical properties of spray dried lactose in the presence of different polyethylene glycols (PEG 400, PEG 3000 and PEG 6000) and to evaluate their performance as carriers for dry powder inhaler (DPI) formulations. The efficiency of spray dried lactose/P...

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Veröffentlicht in:European journal of pharmaceutics and biopharmaceutics 2004-11, Vol.58 (3), p.595-606
Hauptverfasser: Gilani, Kambiz, Rouholamini Najafabadi, Abdolhossien, Barghi, Mohammadali, Rafiee-Tehrani, Morteza
Format: Artikel
Sprache:eng
Schlagworte:
Aerosolisation
Aerosols
Beclomethasone - analysis
Beclomethasone - chemistry
Beclomethasone dipropionate
Crystallinity
Drug Carriers - analysis
Drug Carriers - chemistry
Dry powder inhaler
Fine particle fraction
Lactose
Lactose - analysis
Lactose - chemistry
Polyethylene glycols
Polyethylene Glycols - analysis
Polyethylene Glycols - chemistry
Spray drying
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Zusammenfassung:The aim of this study was to characterize the physical properties of spray dried lactose in the presence of different polyethylene glycols (PEG 400, PEG 3000 and PEG 6000) and to evaluate their performance as carriers for dry powder inhaler (DPI) formulations. The efficiency of spray dried lactose/PEG carriers in aerosolisation of beclomethasone dipropionate (BD), a model hydrophobic drug, was compared to Pharmatose ® 325 M (L325), spray dried lactose alone (SDL), and also a sieved (
ISSN:0939-6411
1873-3441
DOI:10.1016/j.ejpb.2004.04.011