Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS

Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS

A novel series of 2-(α-methylbenzylamino) pyrazines have been synthesized and shown to be potent inhibitors of the FMS tyrosine receptor kinase. A series of 2-(α-methylbenzylamino) pyrazines have shown to be potent inhibitors of the FMS tyrosine receptor kinase. Details of SAR studies, modeling and...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2009-02, Vol.19 (4), p.1206-1209
Hauptverfasser: Burns, Christopher J., Harte, Michael F., Bu, Xianyong, Fantino, Emmanuelle, Giarrusso, Marilena, Joffe, Max, Kurek, Margarita, Legge, Fiona S., Razzino, Pasquale, Su, Stephen, Treutlein, Herbert, Wan, Soo San, Zeng, Jun, Wilks, Andrew F.
Format: Artikel
Sprache:eng
Schlagworte:
Combinatorial Chemistry Techniques
CSF-1
CSF-1R
Drug Design
FMS
Kinase inhibitor
M-CSF-1
Macrophage
Models, Molecular
Molecular Structure
Pyrazines - chemical synthesis
Pyrazines - chemistry
Pyrazines - pharmacology
Receptor, Macrophage Colony-Stimulating Factor - antagonists & inhibitors
Stereoisomerism
Structure-Activity Relationship
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Zusammenfassung:A novel series of 2-(α-methylbenzylamino) pyrazines have been synthesized and shown to be potent inhibitors of the FMS tyrosine receptor kinase. A series of 2-(α-methylbenzylamino) pyrazines have shown to be potent inhibitors of the FMS tyrosine receptor kinase. Details of SAR studies, modeling and synthesis of compounds within this series are reported.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2008.12.073