A General Method for the Synthesis of Unsymmetrically Substituted Ureas via Palladium-Catalyzed Amidation

A general and practical method for the preparation of unsymmetrically substituted ureas has been developed utilizing palladium-catalyzed amidation. Both aryl bromides and chlorides, as well as heteroaryl chlorides, have been coupled to aryl, benzyl, and aliphatic ureas by using a novel nonproprietar...

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Veröffentlicht in:	Organic letters 2009-02, Vol.11 (4), p.947-950
Hauptverfasser:	Kotecki, Brian J, Fernando, Dilinie P, Haight, Anthony R, Lukin, Kirill A
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Combinatorial Chemistry Techniques Molecular Structure Palladium - chemistry Urea - analogs & derivatives Urea - chemical synthesis Urea - chemistry
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Beschreibung
Zusammenfassung:	A general and practical method for the preparation of unsymmetrically substituted ureas has been developed utilizing palladium-catalyzed amidation. Both aryl bromides and chlorides, as well as heteroaryl chlorides, have been coupled to aryl, benzyl, and aliphatic ureas by using a novel nonproprietary bipyrazole ligand (bippyphos).
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol802931m