Unprecedented Acceleration of Zirconium(IV)-Assisted Peptide Hydrolysis at Neutral pH

Unprecedented Acceleration of Zirconium(IV)-Assisted Peptide Hydrolysis at Neutral pH

4,13-Diaza-18-crown-6 substantially increases the rate of zirconium(IV) hydrolysis of unactivated peptide amide bonds under near-physiological conditions of temperature and pH. In the presence of this azacrown ether, ZrCl4 efficiently hydrolyses both neutral and negatively charged peptides (pH 7.0−7...

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Veröffentlicht in:Inorganic chemistry 2004-10, Vol.43 (20), p.6130-6132
Hauptverfasser: Kassai, Miki, Ravi, R. Gnana, Shealy, Sarah J, Grant, Kathryn B
Format: Artikel
Sprache:eng
Schlagworte:
Amides - chemistry
Hydrogen-Ion Concentration
Hydrolysis
Molecular Structure
Peptides - chemistry
Time Factors
Zirconium - chemistry
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Zusammenfassung:4,13-Diaza-18-crown-6 substantially increases the rate of zirconium(IV) hydrolysis of unactivated peptide amide bonds under near-physiological conditions of temperature and pH. In the presence of this azacrown ether, ZrCl4 efficiently hydrolyses both neutral and negatively charged peptides (pH 7.0−7.3, 37−60 °C).
ISSN:0020-1669
1520-510X
DOI:10.1021/ic049433j