A Versatile Approach to β-Amyloid Fibril-Binding Compounds Exploiting the Shirakawa/Hayashi Protocol for trans-Alkene Synthesis

A Versatile Approach to β-Amyloid Fibril-Binding Compounds Exploiting the Shirakawa/Hayashi Protocol for trans-Alkene Synthesis

Application of the Sonogashira coupling reaction followed by a trans-selective alkyne reduction proved highly adaptable for the efficient synthesis of a class of β-amyloid fibril binding compounds possessing a styrylbenzene motif such as FSB, an FSB dimer, and 19F-BAY94-9172.

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Veröffentlicht in:Organic letters 2009-02, Vol.11 (4), p.999-1002
Hauptverfasser: Huynh, Tri H. V, Mantel, Mette Louise H, Mikkelsen, Katrine, Lindhardt, Anders T, Nielsen, Niels Chr, Otzen, Daniel, Skrydstrup, Troels
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes - chemical synthesis
Alkynes - chemistry
Amyloid beta-Peptides - metabolism
Aniline Compounds - chemical synthesis
Aniline Compounds - chemistry
Molecular Structure
Protein Binding
Stereoisomerism
Stilbenes - chemical synthesis
Stilbenes - chemistry
Styrenes - chemical synthesis
Styrenes - chemistry
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Beschreibung
Zusammenfassung:Application of the Sonogashira coupling reaction followed by a trans-selective alkyne reduction proved highly adaptable for the efficient synthesis of a class of β-amyloid fibril binding compounds possessing a styrylbenzene motif such as FSB, an FSB dimer, and 19F-BAY94-9172.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol8029593