Aerosolization properties, surface composition and physical state of spray-dried protein powders

Powder aerosols made of albumin, dipalmitoylphosphatidylcholine (DPPC) and a protein stabilizer (lactose, trehalose or mannitol) were prepared by spray-drying and analyzed for aerodynamic behavior, surface composition and physical state. The powders exited a Spinhaler™ inhaler as particle aggregates...

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Veröffentlicht in:	Journal of controlled release 2004-10, Vol.99 (3), p.357-367
Hauptverfasser:	Bosquillon, Cynthia, Rouxhet, Paul G., Ahimou, François, Simon, Denis, Culot, Christine, Préat, Véronique, Vanbever, Rita
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2-Dipalmitoylphosphatidylcholine - administration & dosage 1,2-Dipalmitoylphosphatidylcholine - chemistry Administration, Inhalation Aerosols - administration & dosage Albumin Albumins - administration & dosage Albumins - chemistry Biological and medical sciences Chemistry, Pharmaceutical - methods Crystallization Dipalmitoylphosphatidylcholine Drug Carriers - administration & dosage Drug Carriers - chemistry Drug Stability Dry powder aerosols Excipients - administration & dosage Excipients - chemistry Fine particle fraction General pharmacology Humans Lactose - analysis Medical sciences Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Porosity Powders - administration & dosage Powders - chemistry Protein Denaturation Spectrometry, X-Ray Emission - methods Spray-drying Surface Properties Water - analysis Water sorption Wettability X-ray diffraction X-ray photoelectron spectroscopy
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Zusammenfassung:	Powder aerosols made of albumin, dipalmitoylphosphatidylcholine (DPPC) and a protein stabilizer (lactose, trehalose or mannitol) were prepared by spray-drying and analyzed for aerodynamic behavior, surface composition and physical state. The powders exited a Spinhaler™ inhaler as particle aggregates, the size of which depending on composition, spray-drying parameters and airflow rate. However, due to low bulk powder tap density (
ISSN:	0168-3659 1873-4995
DOI:	10.1016/j.jconrel.2004.07.022