Effect of topical pimecrolimus on epicutaneous skin testing

Pimecrolimus cream 1% is a safe and effective treatment for atopic dermatitis.2,3 In addition, pimecrolimus has been shown to inhibit the release of proinflammatory mediators from mast cells in vitro.4 If pimecrolimus can prevent the release of histamine from mast cells, there is a possibility of fa...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2004-09, Vol.114 (3), p.695-697
Hauptverfasser:	Spergel, Jonathan M., Nurse, Nicole, Taylor, Paulette, ParneixSpake, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Administration, Topical Adult Allergens - administration & dosage Allergens - adverse effects Allergies Animals Cats Dermatitis Dermatitis, Atopic - drug therapy Dogs Double-Blind Method False Negative Reactions Humans Hypersensitivity - diagnosis Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - therapeutic use Skin Tests Tacrolimus - administration & dosage Tacrolimus - analogs & derivatives Tacrolimus - therapeutic use
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Beschreibung
Zusammenfassung:	Pimecrolimus cream 1% is a safe and effective treatment for atopic dermatitis.2,3 In addition, pimecrolimus has been shown to inhibit the release of proinflammatory mediators from mast cells in vitro.4 If pimecrolimus can prevent the release of histamine from mast cells, there is a possibility of false-negative skin tests, affecting the diagnosis of patients. [...]the intermittent use of pimecrolimus cream 1% does not appear to have a significant effect on skin tests.
ISSN:	0091-6749 1097-6825
DOI:	10.1016/j.jaci.2004.05.067