Fibrinogen and its oxidized form induce interleukin-8 [correction of interleukin-2] production in cultured endothelial cells of human vessels

Oxidized fibrinogen was more potent than native fibrinogen in inducing interleukin-8 production in primary culture of human endothelial cells. The optimal concentration of oxidized fibrinogen was 3 mg/ml. The optimal time of UV irradiation was 17 min. Secretion of interleukin-8 was maximum during cu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of experimental biology and medicine 2004-04, Vol.137 (4), p.358-360
Hauptverfasser:	Azizova, O A, Maksyanina, E V, Romanov, Yu A, Aseichev, A V, Scheglovitova, O N
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Culture Media, Serum-Free Endothelial Cells - cytology Endothelial Cells - metabolism Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Fibrinogen - metabolism Humans Interleukin-8 - metabolism Oxidation-Reduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Oxidized fibrinogen was more potent than native fibrinogen in inducing interleukin-8 production in primary culture of human endothelial cells. The optimal concentration of oxidized fibrinogen was 3 mg/ml. The optimal time of UV irradiation was 17 min. Secretion of interleukin-8 was maximum during culturing of endothelial cells in a serum-free medium.
ISSN:	0007-4888