Comparison of Quantum Dot Biodistribution with a Blood-Flow-Limited Physiologically Based Pharmacokinetic Model

A physiologically based pharmacokinetic model with partition coefficients estimated from quantum dot (QD) 705 biodistribution was compared with the biodistribution of other QDs in mice and rats to determine the model’s predictive ability across QD types, species, and exposure routes. The model predi...

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Veröffentlicht in:	Nano letters 2009-02, Vol.9 (2), p.794-799
Hauptverfasser:	Lee, Hyun A, Leavens, Teresa L, Mason, Sharon E, Monteiro-Riviere, Nancy A, Riviere, Jim E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Applied sciences Cross-disciplinary physics: materials science rheology Electronics Exact sciences and technology Hemodynamics Materials science Mice Models, Biological Molecular electronics, nanoelectronics Nanocrystalline materials Nanoscale materials and structures: fabrication and characterization Organ Specificity Pharmacokinetics Physics Quantum Dots Rats Semiconductor electronics. Microelectronics. Optoelectronics. Solid state devices Tissue Distribution
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Zusammenfassung:	A physiologically based pharmacokinetic model with partition coefficients estimated from quantum dot (QD) 705 biodistribution was compared with the biodistribution of other QDs in mice and rats to determine the model’s predictive ability across QD types, species, and exposure routes. The model predicted the experimentally observed persistence of QDs in tissues but not early time profiles or different QD biodistribution. Therefore, more complex models will be needed to better predict QD biodistribution in vivo.
ISSN:	1530-6984 1530-6992
DOI:	10.1021/nl803481q