Complete Replacement of H2 by D2 via Pd/C-Catalyzed H/D Exchange Reaction

Complete Replacement of H2 by D2 via Pd/C-Catalyzed H/D Exchange Reaction

A general and in situ D2 gas generation method using 10% Pd/C-catalyzed H2−D2 exchange reaction in a H2−D2O system has been developed. H2 gas sealed in a reaction flask was efficiently converted into nearly pure D2 gas, which can be used for the reductive deuteration of substrates possessing reducib...

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Veröffentlicht in:Organic letters 2004-09, Vol.6 (20), p.3521-3523
Hauptverfasser: Sajiki, Hironao, Kurita, Takanori, Esaki, Hiroyoshi, Aoki, Fumiyo, Maegawa, Tomohiro, Hirota, Kosaku
Format: Artikel
Sprache:eng
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Zusammenfassung:A general and in situ D2 gas generation method using 10% Pd/C-catalyzed H2−D2 exchange reaction in a H2−D2O system has been developed. H2 gas sealed in a reaction flask was efficiently converted into nearly pure D2 gas, which can be used for the reductive deuteration of substrates possessing reducible functionalities within the molecule.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol048591b