Defects in the prostaglandin system—What is known?

The central role of prostaglandins as local mediators is well accepted. Molecular biology and in particular knock-out mice models teach us a lot on mechanisms and eventual biological consequences. Despite the broad basic knowledge available, human data on defects in the prostaglandin system are extr...

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Veröffentlicht in:	Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2004-11, Vol.71 (5), p.347-350
Hauptverfasser:	Reiter, Rosemarie A., Peskar, Bernhard A., Sinzinger, Helmut
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acid - metabolism Biological and medical sciences Blood Platelets Epoprostenol Fundamental and applied biological sciences. Psychology Hemorrhage Humans Lipoxygenase Prostaglandin-Endoperoxide Synthases Prostaglandins - genetics Prostaglandins - physiology Thrombosis Thromboxane-A Synthase Vertebrates: endocrinology
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Beschreibung
Zusammenfassung:	The central role of prostaglandins as local mediators is well accepted. Molecular biology and in particular knock-out mice models teach us a lot on mechanisms and eventual biological consequences. Despite the broad basic knowledge available, human data on defects in the prostaglandin system are extremely rare. Why? Don’t we search for them? Are they of clinical relevance? What is their prevalence, the outcome? How to treat, if possible? For this purpose we are planning a platform and databank to improve knowledge, pool information and allow exchange of probes. All interested people are invited to join.
ISSN:	0952-3278 1532-2823
DOI:	10.1016/j.plefa.2004.07.003