Resistance to fatigue of individual Xenopus single skeletal muscle fibres is correlated with mitochondrial volume density

Resistance to fatigue of individual Xenopus single skeletal muscle fibres is correlated with mitochondrial volume density

The purpose of the present study was to compare the individual fatigue characteristics of isolated single skeletal muscle fibres with their mitochondrial volume density (MVD), using direct histological morphometry. Single muscle fibres ( n = 14) were microdissected from lumbrical muscle of adult fem...

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Veröffentlicht in:Experimental physiology 2004-09, Vol.89 (5), p.617-621
Hauptverfasser: Stary, Creed M., Mathieu‐Costello, Odile, Hogan, Michael C.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Size
Female
Mitochondria - physiology
Mitochondria - ultrastructure
Muscle Fatigue - physiology
Muscle Fibers, Skeletal - physiology
Muscle Fibers, Skeletal - ultrastructure
Muscle, Skeletal - physiology
Muscle, Skeletal - ultrastructure
Xenopus laevis
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Zusammenfassung:The purpose of the present study was to compare the individual fatigue characteristics of isolated single skeletal muscle fibres with their mitochondrial volume density (MVD), using direct histological morphometry. Single muscle fibres ( n = 14) were microdissected from lumbrical muscle of adult female Xenopus laevis , and force was measured while fibres were stimulated (tetanic contractions of 200 ms trains with 70 Hz stimuli at 9 V) at progressively increasing frequencies (2 min each at 0.25, 0.33, 0.5 and 1 contractions s −1 ) until fatigue (
ISSN:0958-0670
1469-445X
DOI:10.1113/expphysiol.2004.027763