COMBINED EFFECTS OF ARBEKACIN WITH BIAPENEM AGAINST IN VITRO AND IN VIVO MODEL OF A MIXTURE OF MRSA AND Pseudomonas aeruginosa

Combinede ffectso f arbekacin (A BK) with biapenem (BIPM) w eree xaminedo n both i n vitro and in vivo model of a mixtureo f MRSA and Pseudomonaase ruginosa As a result, significan etffect in vitrow aso bserved in combined use of ABK (1/2 MIC) with BIPM (1/4 and 1/2 MIC) against MRSA as compared with ABK or BIPM alone. Against P aeruginosa combined effect was also observed, showing reduction of viable cells to the limitation of detection within 2 hours. Moreover, with respect to the protective effect on mixed systemic infection of MRSA and P aeruginosa, the combined treatment with ABK and BIPM showed more excellent efficacy as compared with the single use of each drug.