Ca2+ regulation and gene expression in normal brain aging

Understanding the cellular mechanisms that characterize the functional changes of the aged brain is an ongoing and formidable challenge for the neuroscience community. Evidence now links changes in Ca(2+) influx and homeostasis with perturbations induced by the aging process in the function of the m...

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Veröffentlicht in:	Trends in neurosciences (Regular ed.) 2004-10, Vol.27 (10), p.614-620
Hauptverfasser:	TOESCU, Emil C, VERKHRATSKY, Alexei, LANDFIELD, Philip W
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - physiology Animals Biological and medical sciences Brain Brain - physiology Calcium - metabolism Calcium Signaling - physiology Development. Senescence. Regeneration. Transplantation Endoplasmic Reticulum - physiology Fundamental and applied biological sciences. Psychology Gene Expression Regulation - physiology Genes Homeostasis - physiology Humans Mitochondria - physiology Neurons - physiology Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Understanding the cellular mechanisms that characterize the functional changes of the aged brain is an ongoing and formidable challenge for the neuroscience community. Evidence now links changes in Ca(2+) influx and homeostasis with perturbations induced by the aging process in the function of the main intracellular organelles involved in Ca(2+) regulation: the endoplasmic reticulum and mitochondria. New perspectives are also offered by recent gene microarray studies, illustrating the multifactorial nature of the aging process.
ISSN:	0166-2236 1878-108X
DOI:	10.1016/j.tins.2004.07.010