Out-Foxing Fate: Molecular Switches Create Neuronal Diversity in the Retina

Out-Foxing Fate: Molecular Switches Create Neuronal Diversity in the Retina

Progenitor cells in the mammalian retina generate at least 55 distinct kinds of neurons. Two reports in this issue of Neuron reveal two transcription factors (Foxn4 and Bhlhb4) that contribute to the development of this remarkable cellular diversity.

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Bibliographische Detailangaben
Veröffentlicht in:Neuron 2004-09, Vol.43 (6), p.759-760
Hauptverfasser: Kay, Jeremy N., Baier, Herwig
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Basic Helix-Loop-Helix Transcription Factors
Eye Proteins - metabolism
Forkhead Transcription Factors
Genes
Genes, Switch - physiology
Light
Mammalia
Mice
Neurons
Neurons - physiology
Photoreceptors
Retina
Retina - cytology
Retina - physiology
Spinal cord
Stem Cells - physiology
Transcription factors
Transcription Factors - metabolism
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Beschreibung
Zusammenfassung:Progenitor cells in the mammalian retina generate at least 55 distinct kinds of neurons. Two reports in this issue of Neuron reveal two transcription factors (Foxn4 and Bhlhb4) that contribute to the development of this remarkable cellular diversity.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2004.09.001