Peripheral opiate action on afferent fibres supplying the rat intestine

The aim of the present study was to examine the sensitivity of mesenteric afferents supplying the rat small intestine to µ‐opioid receptor ligands. Mesenteric afferent discharge was recorded electrophysiologically in response to [D‐ALA2, N‐Me‐Phe4, Gly5‐ol]‐enkephalin (DAMGO; 100 µg kg−1 i.v.), befo...

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Veröffentlicht in:	Neurogastroenterology and motility 2004-10, Vol.16 (s2), p.29-37
Hauptverfasser:	Grundy, D., Booth, C. E., Winchester, W., Hicks, G. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	5‐HT Action Potentials - drug effects Action Potentials - physiology afferents Animals bradykinin Enkephalin, Ala-MePhe-Gly- - pharmacology Jejunum - drug effects Jejunum - physiology Male mechanosensitivity Narcotic Antagonists Narcotics - pharmacology Neurons, Afferent - drug effects Neurons, Afferent - physiology opiate analgesic opioids Piperidines - pharmacology Rats Rats, Sprague-Dawley Receptors, Opioid - agonists Receptors, Opioid - physiology small intestine
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Zusammenfassung:	The aim of the present study was to examine the sensitivity of mesenteric afferents supplying the rat small intestine to µ‐opioid receptor ligands. Mesenteric afferent discharge was recorded electrophysiologically in response to [D‐ALA2, N‐Me‐Phe4, Gly5‐ol]‐enkephalin (DAMGO; 100 µg kg−1 i.v.), before and after treatment with the µ‐receptor antagonist alvimopan (1 mg kg−1 i.v.). DAMGO markedly stimulated whole nerve mesenteric afferent discharge (P
ISSN:	1350-1925 1365-2982
DOI:	10.1111/j.1743-3150.2004.00557.x