Total Synthesis of FR901483

Total Synthesis of FR901483

The architecturally sophisticated skeleton of the immunosuppressive alkaloid FR901483 was assembled via a process relying on the reaction of an in situ generated imine with a suitably disposed donor−acceptor cyclopropane. A short sequence of functional group transformations provided the natural prod...

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Veröffentlicht in:Organic letters 2009-02, Vol.11 (3), p.777-779
Hauptverfasser: Carson, Cheryl A, Kerr, Michael A
Format: Artikel
Sprache:eng
Schlagworte:
Alkaloids - chemical synthesis
Alkaloids - chemistry
Hypocreales - chemistry
Immunosuppressive Agents - chemical synthesis
Immunosuppressive Agents - chemistry
Molecular Structure
Organophosphorus Compounds - chemical synthesis
Organophosphorus Compounds - chemistry
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Zusammenfassung:The architecturally sophisticated skeleton of the immunosuppressive alkaloid FR901483 was assembled via a process relying on the reaction of an in situ generated imine with a suitably disposed donor−acceptor cyclopropane. A short sequence of functional group transformations provided the natural product in an efficient manner.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol802870c