Type 1 diabetes compromises plasma arachidonic and docosahexaenoic acids in newborn babies

The activity of Δ6‐ and Δ5‐desaturase, enzymes required for the synthesis of AA and DHA, are impaired in human and experimental diabetes. We have investigated whether neonates of type 1 diabetic women have compromised plasma AA and DHA at birth. Cord blood was obtained from healthy babies born to mo...

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Veröffentlicht in:	Lipids 2004-04, Vol.39 (4), p.335-342
Hauptverfasser:	Ghebremeskel, K, Thomas, B, Lowy, C, Min, Y, Crawford, M.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Anthropometry arachidonic acid Arachidonic Acid - blood Blood Glucose - metabolism blood plasma Demography Diabetes Diabetes Mellitus, Type 1 - blood docosahexaenoic acid Docosahexaenoic Acids - blood Esters Female Fetal Blood - chemistry Gestational Age Humans Infant Infant, Newborn - blood insulin-dependent diabetes mellitus Male Medical research Metabolites mothers Neonates Plasma Pregnancy Pregnancy in Diabetics
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Zusammenfassung:	The activity of Δ6‐ and Δ5‐desaturase, enzymes required for the synthesis of AA and DHA, are impaired in human and experimental diabetes. We have investigated whether neonates of type 1 diabetic women have compromised plasma AA and DHA at birth. Cord blood was obtained from healthy babies born to mothers with (n=31) and without (n=59) type 1 diabetes. FA composition of plasma choline phosphoglycerides (CPG), TG, and cholesterol esters (CE) was assayed. The neonates of the diabetics had lower levels of AA (20∶4n−6, P
ISSN:	0024-4201 1558-9307
DOI:	10.1007/s11745-004-1237-z