Association of Serotype of Streptococcus pneumoniae With Risk of Severe and Fatal Outcome
BACKGROUND:Invasive pneumococcal disease (IPD) in children may manifest as bacteremia/sepsis, bacteremic pneumonia, or meningitis, with serious outcomes that include hospitalization, neurologic sequelae, or death. The risk of severe or fatal outcome of disease is associated with host-related factors...
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| Veröffentlicht in: | The Pediatric infectious disease journal 2009-02, Vol.28 (2), p.118-122 |
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| container_title | The Pediatric infectious disease journal |
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| creator | Rückinger, Simon von Kries, Rüdiger Siedler, Annette van der Linden, Mark |
| description | BACKGROUND:Invasive pneumococcal disease (IPD) in children may manifest as bacteremia/sepsis, bacteremic pneumonia, or meningitis, with serious outcomes that include hospitalization, neurologic sequelae, or death. The risk of severe or fatal outcome of disease is associated with host-related factors, such as age or comorbid conditions. Furthermore, there is an ongoing discussion about organism-related factors, such as the pneumococcal serotype.
METHODS:Data on 494 children aged |
| doi_str_mv | 10.1097/INF.0b013e318187e215 |
| format | Article |
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METHODS:Data on 494 children aged <16 years hospitalized for IPD between 1997 and 2003 in pediatric hospitals in Germany were analyzed. Serotype specific case-fatality rates and rates of severe outcome were compared using standardized mortality ratios (SMR). The risk of severe or fatal outcome for the serotype with the highest case-fatality rate was further analyzed using multivariate logistic regression adjusting for age younger than 1 year, meningitis, sex, and immunocompromised status as potential confounders.
RESULTS:The overall case-fatality rate was 5.3% and the rate of severe outcome was 17.0%. Serotype 7F had the highest case-fatality rate (14.8%, SMR 3.1), followed by serotypes 23F (8.3%, SMR 1.7) and 3 (8.3%, SMR 1.7). The highest rate of severe outcome was also observed for 7F (40.7%, SMR 2.4). Multivariate analysis showed an odds ratio of 4.3 (1.3–14.7) for fatal outcome and 4.0 (1.6–10.4) for severe outcome comparing 7F to all other serotypes.
CONCLUSIONS:In this study population, serotype 7F accounted for a higher risk of severe and fatal outcome than other serotypes of Streptococcus pneumoniae. In describing the epidemiology of IPD, the serotype-specific risk for severe or fatal outcome is an important complement to other serotype-specific aspects like incidence and antibiotic resistance pattern.</description><identifier>ISSN: 0891-3668</identifier><identifier>EISSN: 1532-0987</identifier><identifier>DOI: 10.1097/INF.0b013e318187e215</identifier><identifier>PMID: 19116604</identifier><identifier>CODEN: PIDJEV</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adolescent ; Bacterial diseases ; Biological and medical sciences ; Child ; Child, Preschool ; Female ; Human bacterial diseases ; Humans ; Infant ; Infectious diseases ; Male ; Medical sciences ; Multivariate Analysis ; Odds Ratio ; Pneumococcal Infections - microbiology ; Pneumococcal Infections - mortality ; Retrospective Studies ; Risk Factors ; Serotyping ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; Streptococcus pneumoniae - classification</subject><ispartof>The Pediatric infectious disease journal, 2009-02, Vol.28 (2), p.118-122</ispartof><rights>2009 Lippincott Williams & Wilkins, Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3808-93c5099fae3ba1b912de85b597ae52464ed43fb35843c2f6bdac5e5b873983313</citedby><cites>FETCH-LOGICAL-c3808-93c5099fae3ba1b912de85b597ae52464ed43fb35843c2f6bdac5e5b873983313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21119985$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19116604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rückinger, Simon</creatorcontrib><creatorcontrib>von Kries, Rüdiger</creatorcontrib><creatorcontrib>Siedler, Annette</creatorcontrib><creatorcontrib>van der Linden, Mark</creatorcontrib><title>Association of Serotype of Streptococcus pneumoniae With Risk of Severe and Fatal Outcome</title><title>The Pediatric infectious disease journal</title><addtitle>Pediatr Infect Dis J</addtitle><description>BACKGROUND:Invasive pneumococcal disease (IPD) in children may manifest as bacteremia/sepsis, bacteremic pneumonia, or meningitis, with serious outcomes that include hospitalization, neurologic sequelae, or death. The risk of severe or fatal outcome of disease is associated with host-related factors, such as age or comorbid conditions. Furthermore, there is an ongoing discussion about organism-related factors, such as the pneumococcal serotype.
METHODS:Data on 494 children aged <16 years hospitalized for IPD between 1997 and 2003 in pediatric hospitals in Germany were analyzed. Serotype specific case-fatality rates and rates of severe outcome were compared using standardized mortality ratios (SMR). The risk of severe or fatal outcome for the serotype with the highest case-fatality rate was further analyzed using multivariate logistic regression adjusting for age younger than 1 year, meningitis, sex, and immunocompromised status as potential confounders.
RESULTS:The overall case-fatality rate was 5.3% and the rate of severe outcome was 17.0%. Serotype 7F had the highest case-fatality rate (14.8%, SMR 3.1), followed by serotypes 23F (8.3%, SMR 1.7) and 3 (8.3%, SMR 1.7). The highest rate of severe outcome was also observed for 7F (40.7%, SMR 2.4). Multivariate analysis showed an odds ratio of 4.3 (1.3–14.7) for fatal outcome and 4.0 (1.6–10.4) for severe outcome comparing 7F to all other serotypes.
CONCLUSIONS:In this study population, serotype 7F accounted for a higher risk of severe and fatal outcome than other serotypes of Streptococcus pneumoniae. In describing the epidemiology of IPD, the serotype-specific risk for severe or fatal outcome is an important complement to other serotype-specific aspects like incidence and antibiotic resistance pattern.</description><subject>Adolescent</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Odds Ratio</subject><subject>Pneumococcal Infections - microbiology</subject><subject>Pneumococcal Infections - mortality</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Serotyping</subject><subject>Staphylococcal infections, streptococcal infections, pneumococcal infections</subject><subject>Streptococcus pneumoniae - classification</subject><issn>0891-3668</issn><issn>1532-0987</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkV1P3TAMhiMEGmewf4Cm3sBdmd0kbXKJEGdDQkPiQ9OuojR1dTrapktSEP9-ZedoSLuxLet5bfk1YycI5wi6-nL9fX0ONSAnjgpVRQXKPbZCyYsctKr22QqUxpyXpTpkH2P8BQBcIHxgh6gRyxLEiv28iNG7zqbOj5lvs3sKPr1O9LdOgabknXdujtk00jz4sbOU_ejSJrvr4tNW8UyBMjs22dom22e3c3J-oGN20No-0qddPmKP66uHy2_5ze3X68uLm9xxBSrX3EnQurXEa4u1xqIhJWupK0uyEKWgRvC25lIJ7oq2rBvrJMlaVVwrzpEfsbPt3Cn43zPFZIYuOup7O5Kfo1nOL6GoxAKKLeiCjzFQa6bQDTa8GgTzZqlZLDX_W7rIPu_mz_VAzbto5-ECnO4AG53t22BH18V_XIGIWiv5vv_F94lCfOrnFwpmQ7ZPG7M8B0ohRV4AaFgC5G8txf8APcGPGw</recordid><startdate>200902</startdate><enddate>200902</enddate><creator>Rückinger, Simon</creator><creator>von Kries, Rüdiger</creator><creator>Siedler, Annette</creator><creator>van der Linden, Mark</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200902</creationdate><title>Association of Serotype of Streptococcus pneumoniae With Risk of Severe and Fatal Outcome</title><author>Rückinger, Simon ; von Kries, Rüdiger ; Siedler, Annette ; van der Linden, Mark</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3808-93c5099fae3ba1b912de85b597ae52464ed43fb35843c2f6bdac5e5b873983313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Odds Ratio</topic><topic>Pneumococcal Infections - microbiology</topic><topic>Pneumococcal Infections - mortality</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Serotyping</topic><topic>Staphylococcal infections, streptococcal infections, pneumococcal infections</topic><topic>Streptococcus pneumoniae - classification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rückinger, Simon</creatorcontrib><creatorcontrib>von Kries, Rüdiger</creatorcontrib><creatorcontrib>Siedler, Annette</creatorcontrib><creatorcontrib>van der Linden, Mark</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Pediatric infectious disease journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rückinger, Simon</au><au>von Kries, Rüdiger</au><au>Siedler, Annette</au><au>van der Linden, Mark</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Serotype of Streptococcus pneumoniae With Risk of Severe and Fatal Outcome</atitle><jtitle>The Pediatric infectious disease journal</jtitle><addtitle>Pediatr Infect Dis J</addtitle><date>2009-02</date><risdate>2009</risdate><volume>28</volume><issue>2</issue><spage>118</spage><epage>122</epage><pages>118-122</pages><issn>0891-3668</issn><eissn>1532-0987</eissn><coden>PIDJEV</coden><abstract>BACKGROUND:Invasive pneumococcal disease (IPD) in children may manifest as bacteremia/sepsis, bacteremic pneumonia, or meningitis, with serious outcomes that include hospitalization, neurologic sequelae, or death. The risk of severe or fatal outcome of disease is associated with host-related factors, such as age or comorbid conditions. Furthermore, there is an ongoing discussion about organism-related factors, such as the pneumococcal serotype.
METHODS:Data on 494 children aged <16 years hospitalized for IPD between 1997 and 2003 in pediatric hospitals in Germany were analyzed. Serotype specific case-fatality rates and rates of severe outcome were compared using standardized mortality ratios (SMR). The risk of severe or fatal outcome for the serotype with the highest case-fatality rate was further analyzed using multivariate logistic regression adjusting for age younger than 1 year, meningitis, sex, and immunocompromised status as potential confounders.
RESULTS:The overall case-fatality rate was 5.3% and the rate of severe outcome was 17.0%. Serotype 7F had the highest case-fatality rate (14.8%, SMR 3.1), followed by serotypes 23F (8.3%, SMR 1.7) and 3 (8.3%, SMR 1.7). The highest rate of severe outcome was also observed for 7F (40.7%, SMR 2.4). Multivariate analysis showed an odds ratio of 4.3 (1.3–14.7) for fatal outcome and 4.0 (1.6–10.4) for severe outcome comparing 7F to all other serotypes.
CONCLUSIONS:In this study population, serotype 7F accounted for a higher risk of severe and fatal outcome than other serotypes of Streptococcus pneumoniae. In describing the epidemiology of IPD, the serotype-specific risk for severe or fatal outcome is an important complement to other serotype-specific aspects like incidence and antibiotic resistance pattern.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>19116604</pmid><doi>10.1097/INF.0b013e318187e215</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Bacterial diseases Biological and medical sciences Child Child, Preschool Female Human bacterial diseases Humans Infant Infectious diseases Male Medical sciences Multivariate Analysis Odds Ratio Pneumococcal Infections - microbiology Pneumococcal Infections - mortality Retrospective Studies Risk Factors Serotyping Staphylococcal infections, streptococcal infections, pneumococcal infections Streptococcus pneumoniae - classification |
| title | Association of Serotype of Streptococcus pneumoniae With Risk of Severe and Fatal Outcome |
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