Total Synthesis of (+)-Azinothricin and (+)-Kettapeptin

Total Synthesis of (+)-Azinothricin and (+)-Kettapeptin

Asymmetric total syntheses of (+)-azinothricin and (+)-kettapeptin have been completed through a common new pathway that exploits a highly chemoselective coupling reaction between the fully elaborated cyclodepsipeptide 5 and the glycal activated esters 3 and 4 at the final stages of both respective...

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Veröffentlicht in:Organic letters 2009-02, Vol.11 (3), p.733-736
Hauptverfasser: Hale, Karl J, Manaviazar, Soraya, George, Jonathan H, Walters, Marcus A, Dalby, Stephen M
Format: Artikel
Sprache:eng
Schlagworte:
Depsipeptides - chemical synthesis
Depsipeptides - chemistry
Esters
Molecular Structure
Peptides - chemical synthesis
Peptides - chemistry
Stereoisomerism
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Zusammenfassung:Asymmetric total syntheses of (+)-azinothricin and (+)-kettapeptin have been completed through a common new pathway that exploits a highly chemoselective coupling reaction between the fully elaborated cyclodepsipeptide 5 and the glycal activated esters 3 and 4 at the final stages of both respective syntheses.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol802817t