A Prospective Study of Transsulfuration Biomarkers in Autistic Disorders

The goal of this study was to evaluate transsulfuration metabolites in participants diagnosed with autism spectrum disorders (ASDs). Transsulfuration metabolites, including: plasma reduced glutathione (GSH), plasma oxidized glutathione (GSSG), plasma cysteine, plasma taurine, plasma sulfate, and pla...

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Veröffentlicht in:	Neurochemical research 2009-02, Vol.34 (2), p.386-393
Hauptverfasser:	Geier, David A., Kern, Janet K., Garver, Carolyn R., Adams, James B., Audhya, Tapan, Geier, Mark R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Autistic Disorder - blood Biochemistry Biomarkers - blood Biomedical and Life Sciences Biomedicine Cell Biology Child Child, Preschool Cysteine - blood Female Glutathione - blood Glutathione Disulfide - blood Humans Male Neurochemistry Neurology Neurosciences Original Paper Prospective Studies Sulfates - blood Sulfur - metabolism Taurine - blood
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Zusammenfassung:	The goal of this study was to evaluate transsulfuration metabolites in participants diagnosed with autism spectrum disorders (ASDs). Transsulfuration metabolites, including: plasma reduced glutathione (GSH), plasma oxidized glutathione (GSSG), plasma cysteine, plasma taurine, plasma sulfate, and plasma free sulfate among participants diagnosed with ASDs (n = 38) in comparison to age-matched neurotypical controls were prospectively evaluated. Testing was conducted using Vitamin Diagnostics, Inc. (CLIA-approved). Participants diagnosed with ASDs had significantly ( P
ISSN:	0364-3190 1573-6903
DOI:	10.1007/s11064-008-9782-x