Stobadine-modulated human neutrophil functional responsiveness: Effect on particular and soluble stimulation

The effect of stobadine on degranulation (myeloperoxidase release) and on oxidative burst, measured as superoxide anion production, was investigated in human neutrophils activated with receptor-specific (fMLP, opsonized zymosan) and nonreceptor stimuli (PMA, A 23187). Wortmannin, a specific inhibito...

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Veröffentlicht in:	Methods and findings in experimental and clinical pharmacology 2004-07, Vol.26 (6), p.395-398
Hauptverfasser:	PECIVOVA, J, MACICKOVA, T, NOSAL', R, FABRYOVA, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carbolines - pharmacology Cell Degranulation - drug effects Cell Degranulation - physiology Dose-Response Relationship, Drug Free Radicals - metabolism General pharmacology Humans Medical sciences Neutrophils - drug effects Neutrophils - physiology Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Respiratory Burst - drug effects Respiratory Burst - physiology Solubility - drug effects Superoxides - metabolism
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Zusammenfassung:	The effect of stobadine on degranulation (myeloperoxidase release) and on oxidative burst, measured as superoxide anion production, was investigated in human neutrophils activated with receptor-specific (fMLP, opsonized zymosan) and nonreceptor stimuli (PMA, A 23187). Wortmannin, a specific inhibitor of 1-phosphatidylinositol 3-kinase, significantly inhibited fMLP-stimulated generation only. This effect was pronounced by stobadine. Stobadine dose-dependently decreased superoxide generation and myeloperoxidase release after receptor-specific stimuli, with the highest effect on fMLP stimulation of superoxide generation and on opsonized zymosan stimulation of myeloperoxidase release.
ISSN:	0379-0355