Phenolic Constituents from the Stem Bark of Magnolia officinalis
Three new compounds, magnolianone (1), erythro-honokitriol (2), and threo-honokitriol (3), together with 14 known compounds, magnaldehyde (4), magnatriol B (5), randaiol (6), obovatol (7), magnolignan B (8a and 8b), magnolol, honokiol (9), p-hydroxylbenzaldehyde, coniferaldehyde, coniferol alcohol,...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2009-01, Vol.72 (1), p.168-171 |
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| container_title | Journal of natural products (Washington, D.C.) |
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| creator | Shen, Chien-Chang Ni, Ching-Li Shen, Yuh-Chiang Huang, Yu-Ling Kuo, Ching-Hsia Wu, Tian-Shung Chen, Chien-Chih |
| description | Three new compounds, magnolianone (1), erythro-honokitriol (2), and threo-honokitriol (3), together with 14 known compounds, magnaldehyde (4), magnatriol B (5), randaiol (6), obovatol (7), magnolignan B (8a and 8b), magnolol, honokiol (9), p-hydroxylbenzaldehyde, coniferaldehyde, coniferol alcohol, syringaldehyde, syringaresinol, and acteoside, were isolated from the MeOH-soluble part of a water extract of the stem bark of Magnolia officinalis. Among these compounds, 2−8b were studied for anti-inflammatory and antioxidative activities. Compound 7 displayed more potent antioxidative potential than 9. Compounds 4−7 effectively inhibited LPS-induced NO production, whereas 5 and 6 were more potent than 9. |
| doi_str_mv | 10.1021/np800494e |
| format | Article |
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Among these compounds, 2−8b were studied for anti-inflammatory and antioxidative activities. Compound 7 displayed more potent antioxidative potential than 9. Compounds 4−7 effectively inhibited LPS-induced NO production, whereas 5 and 6 were more potent than 9.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np800494e</identifier><identifier>PMID: 19086868</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Northbrook, IL: American Chemical Society and American Society of Pharmacognosy</publisher><subject>Animals ; anti-inflammatory activity ; Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Anti-Inflammatory Agents, Non-Steroidal - isolation & purification ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; antioxidant activity ; Antioxidants - chemistry ; Antioxidants - isolation & purification ; Antioxidants - pharmacology ; Biological and medical sciences ; Biphenyl Compounds - chemistry ; Biphenyl Compounds - isolation & purification ; Biphenyl Compounds - pharmacology ; chemical structure ; cultured cells ; Cyclohexanones - chemistry ; Cyclohexanones - isolation & purification ; Cyclohexanones - pharmacology ; erythro-honokitriol ; General pharmacology ; human health ; Lignans - pharmacology ; Lipopolysaccharides - pharmacology ; Magnolia ; Magnolia - chemistry ; Magnolia officinalis ; magnolianone ; magnolignan ; Medical sciences ; medicinal plants ; medicinal properties ; Mice ; Microglia - drug effects ; Molecular Structure ; neuroglia ; Nitric Oxide - antagonists & inhibitors ; Nitric Oxide - metabolism ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; phenolic compounds ; Picrates - pharmacology ; Plant Bark - chemistry ; Plants, Medicinal - chemistry ; reactive oxygen species ; spectral analysis ; Taiwan ; threo-honokitriol</subject><ispartof>Journal of natural products (Washington, D.C.), 2009-01, Vol.72 (1), p.168-171</ispartof><rights>Copyright © 2009 American Chemical Society and American Society of Pharmacognosy</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a433t-5b53b82cf78d5cb305d8b2b391d90aa999a5207d927f51af69a429c7379e882d3</citedby><cites>FETCH-LOGICAL-a433t-5b53b82cf78d5cb305d8b2b391d90aa999a5207d927f51af69a429c7379e882d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np800494e$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np800494e$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21088796$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19086868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shen, Chien-Chang</creatorcontrib><creatorcontrib>Ni, Ching-Li</creatorcontrib><creatorcontrib>Shen, Yuh-Chiang</creatorcontrib><creatorcontrib>Huang, Yu-Ling</creatorcontrib><creatorcontrib>Kuo, Ching-Hsia</creatorcontrib><creatorcontrib>Wu, Tian-Shung</creatorcontrib><creatorcontrib>Chen, Chien-Chih</creatorcontrib><title>Phenolic Constituents from the Stem Bark of Magnolia officinalis</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>Three new compounds, magnolianone (1), erythro-honokitriol (2), and threo-honokitriol (3), together with 14 known compounds, magnaldehyde (4), magnatriol B (5), randaiol (6), obovatol (7), magnolignan B (8a and 8b), magnolol, honokiol (9), p-hydroxylbenzaldehyde, coniferaldehyde, coniferol alcohol, syringaldehyde, syringaresinol, and acteoside, were isolated from the MeOH-soluble part of a water extract of the stem bark of Magnolia officinalis. Among these compounds, 2−8b were studied for anti-inflammatory and antioxidative activities. Compound 7 displayed more potent antioxidative potential than 9. Compounds 4−7 effectively inhibited LPS-induced NO production, whereas 5 and 6 were more potent than 9.</description><subject>Animals</subject><subject>anti-inflammatory activity</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - chemistry</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - isolation & purification</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>antioxidant activity</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - isolation & purification</subject><subject>Antioxidants - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Biphenyl Compounds - chemistry</subject><subject>Biphenyl Compounds - isolation & purification</subject><subject>Biphenyl Compounds - pharmacology</subject><subject>chemical structure</subject><subject>cultured cells</subject><subject>Cyclohexanones - chemistry</subject><subject>Cyclohexanones - isolation & purification</subject><subject>Cyclohexanones - pharmacology</subject><subject>erythro-honokitriol</subject><subject>General pharmacology</subject><subject>human health</subject><subject>Lignans - pharmacology</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Magnolia</subject><subject>Magnolia - chemistry</subject><subject>Magnolia officinalis</subject><subject>magnolianone</subject><subject>magnolignan</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>Mice</subject><subject>Microglia - drug effects</subject><subject>Molecular Structure</subject><subject>neuroglia</subject><subject>Nitric Oxide - antagonists & inhibitors</subject><subject>Nitric Oxide - metabolism</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>phenolic compounds</subject><subject>Picrates - pharmacology</subject><subject>Plant Bark - chemistry</subject><subject>Plants, Medicinal - chemistry</subject><subject>reactive oxygen species</subject><subject>spectral analysis</subject><subject>Taiwan</subject><subject>threo-honokitriol</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0UFP2zAUB3ALbVpLtwNfYMtlSBzCnu3YsW-MagMkEJMY5-jFsdt0SVzs5LBvj1Gr9oLewe_w019PfxNyRuGSAqM_hq0CKHRhT8icCga5BCY-kDlQyXOuZDEjpzFuAICDFp_IjGpQMs2cXP1Z28F3rcmWfohjO052GGPmgu-zcW2zp9H22TWGf5l32QOu3iym3bWmHbBr42fy0WEX7Zf9uyDPv3_9Xd7m9483d8uf9zkWnI-5qAWvFTOuVI0wNQfRqJrVXNNGA6LWGtPhZaNZ6QRFJzUWTJuSl9oqxRq-IOe73G3wL5ONY9W30diuw8H6KVZSqkKzQiR4sYMm-BiDddU2tD2G_xWF6q2u6lBXsl_3oVPd2-Yo9_0k8H0PMBrsXMDBtPHgGAWlSi2T-7ZzDn2Fq5DM8xMDytMXMFlIekxCE6uNn0JqL75z0ivEc4YB</recordid><startdate>20090101</startdate><enddate>20090101</enddate><creator>Shen, Chien-Chang</creator><creator>Ni, Ching-Li</creator><creator>Shen, Yuh-Chiang</creator><creator>Huang, Yu-Ling</creator><creator>Kuo, Ching-Hsia</creator><creator>Wu, Tian-Shung</creator><creator>Chen, Chien-Chih</creator><general>American Chemical Society and American Society of Pharmacognosy</general><general>American Society of Pharmacognosy</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090101</creationdate><title>Phenolic Constituents from the Stem Bark of Magnolia officinalis</title><author>Shen, Chien-Chang ; Ni, Ching-Li ; Shen, Yuh-Chiang ; Huang, Yu-Ling ; Kuo, Ching-Hsia ; Wu, Tian-Shung ; Chen, Chien-Chih</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a433t-5b53b82cf78d5cb305d8b2b391d90aa999a5207d927f51af69a429c7379e882d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>anti-inflammatory activity</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - chemistry</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - isolation & purification</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>antioxidant activity</topic><topic>Antioxidants - chemistry</topic><topic>Antioxidants - isolation & purification</topic><topic>Antioxidants - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Biphenyl Compounds - chemistry</topic><topic>Biphenyl Compounds - isolation & purification</topic><topic>Biphenyl Compounds - pharmacology</topic><topic>chemical structure</topic><topic>cultured cells</topic><topic>Cyclohexanones - chemistry</topic><topic>Cyclohexanones - isolation & purification</topic><topic>Cyclohexanones - pharmacology</topic><topic>erythro-honokitriol</topic><topic>General pharmacology</topic><topic>human health</topic><topic>Lignans - pharmacology</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Magnolia</topic><topic>Magnolia - chemistry</topic><topic>Magnolia officinalis</topic><topic>magnolianone</topic><topic>magnolignan</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>Mice</topic><topic>Microglia - drug effects</topic><topic>Molecular Structure</topic><topic>neuroglia</topic><topic>Nitric Oxide - antagonists & inhibitors</topic><topic>Nitric Oxide - metabolism</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>phenolic compounds</topic><topic>Picrates - pharmacology</topic><topic>Plant Bark - chemistry</topic><topic>Plants, Medicinal - chemistry</topic><topic>reactive oxygen species</topic><topic>spectral analysis</topic><topic>Taiwan</topic><topic>threo-honokitriol</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shen, Chien-Chang</creatorcontrib><creatorcontrib>Ni, Ching-Li</creatorcontrib><creatorcontrib>Shen, Yuh-Chiang</creatorcontrib><creatorcontrib>Huang, Yu-Ling</creatorcontrib><creatorcontrib>Kuo, Ching-Hsia</creatorcontrib><creatorcontrib>Wu, Tian-Shung</creatorcontrib><creatorcontrib>Chen, Chien-Chih</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shen, Chien-Chang</au><au>Ni, Ching-Li</au><au>Shen, Yuh-Chiang</au><au>Huang, Yu-Ling</au><au>Kuo, Ching-Hsia</au><au>Wu, Tian-Shung</au><au>Chen, Chien-Chih</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phenolic Constituents from the Stem Bark of Magnolia officinalis</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2009-01-01</date><risdate>2009</risdate><volume>72</volume><issue>1</issue><spage>168</spage><epage>171</epage><pages>168-171</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>Three new compounds, magnolianone (1), erythro-honokitriol (2), and threo-honokitriol (3), together with 14 known compounds, magnaldehyde (4), magnatriol B (5), randaiol (6), obovatol (7), magnolignan B (8a and 8b), magnolol, honokiol (9), p-hydroxylbenzaldehyde, coniferaldehyde, coniferol alcohol, syringaldehyde, syringaresinol, and acteoside, were isolated from the MeOH-soluble part of a water extract of the stem bark of Magnolia officinalis. Among these compounds, 2−8b were studied for anti-inflammatory and antioxidative activities. Compound 7 displayed more potent antioxidative potential than 9. Compounds 4−7 effectively inhibited LPS-induced NO production, whereas 5 and 6 were more potent than 9.</abstract><cop>Northbrook, IL</cop><pub>American Chemical Society and American Society of Pharmacognosy</pub><pmid>19086868</pmid><doi>10.1021/np800494e</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 2009-01, Vol.72 (1), p.168-171 |
| issn | 0163-3864 1520-6025 |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Animals anti-inflammatory activity Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - isolation & purification Anti-Inflammatory Agents, Non-Steroidal - pharmacology antioxidant activity Antioxidants - chemistry Antioxidants - isolation & purification Antioxidants - pharmacology Biological and medical sciences Biphenyl Compounds - chemistry Biphenyl Compounds - isolation & purification Biphenyl Compounds - pharmacology chemical structure cultured cells Cyclohexanones - chemistry Cyclohexanones - isolation & purification Cyclohexanones - pharmacology erythro-honokitriol General pharmacology human health Lignans - pharmacology Lipopolysaccharides - pharmacology Magnolia Magnolia - chemistry Magnolia officinalis magnolianone magnolignan Medical sciences medicinal plants medicinal properties Mice Microglia - drug effects Molecular Structure neuroglia Nitric Oxide - antagonists & inhibitors Nitric Oxide - metabolism Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phenolic compounds Picrates - pharmacology Plant Bark - chemistry Plants, Medicinal - chemistry reactive oxygen species spectral analysis Taiwan threo-honokitriol |
| title | Phenolic Constituents from the Stem Bark of Magnolia officinalis |
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