Phenolic Constituents from the Stem Bark of Magnolia officinalis

Three new compounds, magnolianone (1), erythro-honokitriol (2), and threo-honokitriol (3), together with 14 known compounds, magnaldehyde (4), magnatriol B (5), randaiol (6), obovatol (7), magnolignan B (8a and 8b), magnolol, honokiol (9), p-hydroxylbenzaldehyde, coniferaldehyde, coniferol alcohol,...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2009-01, Vol.72 (1), p.168-171
Hauptverfasser:	Shen, Chien-Chang, Ni, Ching-Li, Shen, Yuh-Chiang, Huang, Yu-Ling, Kuo, Ching-Hsia, Wu, Tian-Shung, Chen, Chien-Chih
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-inflammatory activity Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - isolation & purification Anti-Inflammatory Agents, Non-Steroidal - pharmacology antioxidant activity Antioxidants - chemistry Antioxidants - isolation & purification Antioxidants - pharmacology Biological and medical sciences Biphenyl Compounds - chemistry Biphenyl Compounds - isolation & purification Biphenyl Compounds - pharmacology chemical structure cultured cells Cyclohexanones - chemistry Cyclohexanones - isolation & purification Cyclohexanones - pharmacology erythro-honokitriol General pharmacology human health Lignans - pharmacology Lipopolysaccharides - pharmacology Magnolia Magnolia - chemistry Magnolia officinalis magnolianone magnolignan Medical sciences medicinal plants medicinal properties Mice Microglia - drug effects Molecular Structure neuroglia Nitric Oxide - antagonists & inhibitors Nitric Oxide - metabolism Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phenolic compounds Picrates - pharmacology Plant Bark - chemistry Plants, Medicinal - chemistry reactive oxygen species spectral analysis Taiwan threo-honokitriol
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Beschreibung
Zusammenfassung:	Three new compounds, magnolianone (1), erythro-honokitriol (2), and threo-honokitriol (3), together with 14 known compounds, magnaldehyde (4), magnatriol B (5), randaiol (6), obovatol (7), magnolignan B (8a and 8b), magnolol, honokiol (9), p-hydroxylbenzaldehyde, coniferaldehyde, coniferol alcohol, syringaldehyde, syringaresinol, and acteoside, were isolated from the MeOH-soluble part of a water extract of the stem bark of Magnolia officinalis. Among these compounds, 2−8b were studied for anti-inflammatory and antioxidative activities. Compound 7 displayed more potent antioxidative potential than 9. Compounds 4−7 effectively inhibited LPS-induced NO production, whereas 5 and 6 were more potent than 9.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np800494e