Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host

Initially recognized in infection because of antimicrobial activity (‘tryptophan starvation’), indoleamine 2,3-dioxygenase (IDO) is widely involved in host immune homeostasis and even immune evasion by microbes that establish commensalism or chronic infection. This review deals with recent findings...

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Veröffentlicht in:	Microbes and infection 2009, Vol.11 (1), p.133-141
Hauptverfasser:	Zelante, Teresa, Fallarino, Francesca, Bistoni, Francesco, Puccetti, Paolo, Romani, Luigina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Fundamental and applied biological sciences. Psychology Fungi - enzymology Fungi - genetics Host-Pathogen Interactions Humans Indoleamine 2,3-dioxygenase Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism Kynurenine - metabolism Kynurenines Mice Microbiology Mycoses - immunology Mycoses - microbiology Tryptophan - metabolism Tryptophan starvation
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Beschreibung
Zusammenfassung:	Initially recognized in infection because of antimicrobial activity (‘tryptophan starvation’), indoleamine 2,3-dioxygenase (IDO) is widely involved in host immune homeostasis and even immune evasion by microbes that establish commensalism or chronic infection. This review deals with recent findings that could gain IDO a reputation of Jack-of-all-trades in mammalian host/microbe interactions.
ISSN:	1286-4579 1769-714X
DOI:	10.1016/j.micinf.2008.10.007