A Novel Immunomodulator, FTY720, Prevents Spontaneous Dermatitis in NC/Nga Mice

Oral administration of a novel immunomodulator, FTY720 (0.1 mg/kg, once a week), completely prevented the spontaneous development of dermatitis in NC/Nga mice. It also strongly suppressed hyper IgE production in serum, as well as hypertrophy of the epidermis and the degranulation of granulocytes in...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2004, Vol.27(9), pp.1392-1396
Hauptverfasser:	Kohno, Takeyuki, Tsuji, Takumi, Hirayama, Kaori, Watabe, Kazuhito, Matsumoto, Akiko, Kohno, Tomoko, Fujita, Tetsuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals atopic dermatitis Dermatitis, Atopic - immunology Dermatitis, Atopic - prevention & control Disease Models, Animal Epidermis - drug effects Epidermis - immunology Fingolimod Hydrochloride FTY720 Immunoglobulin E - blood Immunosuppressive Agents - pharmacology Male Mice Mice, Inbred Strains NC/Nga mouse Propylene Glycols - pharmacology Specific Pathogen-Free Organisms Sphingosine - analogs & derivatives Time Factors
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