A Novel Immunomodulator, FTY720, Prevents Spontaneous Dermatitis in NC/Nga Mice

Oral administration of a novel immunomodulator, FTY720 (0.1 mg/kg, once a week), completely prevented the spontaneous development of dermatitis in NC/Nga mice. It also strongly suppressed hyper IgE production in serum, as well as hypertrophy of the epidermis and the degranulation of granulocytes in...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2004, Vol.27(9), pp.1392-1396
Hauptverfasser:	Kohno, Takeyuki, Tsuji, Takumi, Hirayama, Kaori, Watabe, Kazuhito, Matsumoto, Akiko, Kohno, Tomoko, Fujita, Tetsuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals atopic dermatitis Dermatitis, Atopic - immunology Dermatitis, Atopic - prevention & control Disease Models, Animal Epidermis - drug effects Epidermis - immunology Fingolimod Hydrochloride FTY720 Immunoglobulin E - blood Immunosuppressive Agents - pharmacology Male Mice Mice, Inbred Strains NC/Nga mouse Propylene Glycols - pharmacology Specific Pathogen-Free Organisms Sphingosine - analogs & derivatives Time Factors
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Zusammenfassung:	Oral administration of a novel immunomodulator, FTY720 (0.1 mg/kg, once a week), completely prevented the spontaneous development of dermatitis in NC/Nga mice. It also strongly suppressed hyper IgE production in serum, as well as hypertrophy of the epidermis and the degranulation of granulocytes in the skin, all of which were observed in mice in which the dermatitis had become established. These results strongly suggest that FTY720 is a promising candidate for treatment of human atopic dermatitis.
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.27.1392