Pyrrolo[2,1- c][1,4]benzodiazepine–anthraquinone conjugates. Synthesis, DNA binding and cytotoxicity
[Display omitted] New pyrrolobenzodiazepine–anthraquinone hybrids have been designed and synthesized, found to effectively bind to DNA and also exhibit cytotoxicity against many cancer cell lines
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2004-10, Vol.14 (19), p.4907-4909 |
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| container_end_page | 4909 |
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| container_issue | 19 |
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| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 14 |
| creator | Kamal, Ahmed Ramu, R. Khanna, G.B. Ramesh Saxena, Ajit Kumar Shanmugavel, M. Pandita, Renu Moti |
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New pyrrolobenzodiazepine–anthraquinone hybrids have been designed and synthesized, found to effectively bind to DNA and also exhibit cytotoxicity against many cancer cell lines |
| doi_str_mv | 10.1016/j.bmcl.2004.07.036 |
| format | Article |
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New pyrrolobenzodiazepine–anthraquinone hybrids have been designed and synthesized, found to effectively bind to DNA and also exhibit cytotoxicity against many cancer cell lines</description><subject>Anthraquinones</subject><subject>Anthraquinones - chemical synthesis</subject><subject>Anthraquinones - metabolism</subject><subject>Anthraquinones - pharmacology</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - metabolism</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Benzodiazepines - chemical synthesis</subject><subject>Benzodiazepines - metabolism</subject><subject>Benzodiazepines - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Cytotoxicity</subject><subject>DNA - metabolism</subject><subject>DNA binding</subject><subject>Drug Design</subject><subject>General aspects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pharmacology. 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| fulltext | fulltext |
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| ispartof | Bioorganic & medicinal chemistry letters, 2004-10, Vol.14 (19), p.4907-4909 |
| issn | 0960-894X 1464-3405 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Anthraquinones Anthraquinones - chemical synthesis Anthraquinones - metabolism Anthraquinones - pharmacology Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Benzodiazepines - chemical synthesis Benzodiazepines - metabolism Benzodiazepines - pharmacology Biological and medical sciences Cell Line, Tumor Cytotoxicity DNA - metabolism DNA binding Drug Design General aspects Humans Medical sciences Pharmacology. Drug treatments Pyrroles - chemical synthesis Pyrroles - metabolism Pyrroles - pharmacology Pyrrolobenzodiazepines |
| title | Pyrrolo[2,1- c][1,4]benzodiazepine–anthraquinone conjugates. Synthesis, DNA binding and cytotoxicity |
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