Pyrrolo[2,1- c][1,4]benzodiazepine–anthraquinone conjugates. Synthesis, DNA binding and cytotoxicity

[Display omitted] New pyrrolobenzodiazepine–anthraquinone hybrids have been designed and synthesized, found to effectively bind to DNA and also exhibit cytotoxicity against many cancer cell lines

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2004-10, Vol.14 (19), p.4907-4909
Hauptverfasser:	Kamal, Ahmed, Ramu, R., Khanna, G.B. Ramesh, Saxena, Ajit Kumar, Shanmugavel, M., Pandita, Renu Moti
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthraquinones Anthraquinones - chemical synthesis Anthraquinones - metabolism Anthraquinones - pharmacology Antineoplastic agents Antineoplastic Agents - chemical synthesis Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Benzodiazepines - chemical synthesis Benzodiazepines - metabolism Benzodiazepines - pharmacology Biological and medical sciences Cell Line, Tumor Cytotoxicity DNA - metabolism DNA binding Drug Design General aspects Humans Medical sciences Pharmacology. Drug treatments Pyrroles - chemical synthesis Pyrroles - metabolism Pyrroles - pharmacology Pyrrolobenzodiazepines
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	[Display omitted] New pyrrolobenzodiazepine–anthraquinone hybrids have been designed and synthesized, found to effectively bind to DNA and also exhibit cytotoxicity against many cancer cell lines
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2004.07.036