Difference of caveolin-1 expression pattern in human lung neoplastic tissue. Atypical adenomatous hyperplasia, adenocarcinoma and squamous cell carcinoma
Caveolin-1 has been implicated in cellular transformation and tumorigenesis. We assessed lung cancer specimens for caveolin-1 expression immunohistochemistry. A majority of the cell types in the lung and the bronchial epithelium normally exhibited positive staining for caveolin-1. In adenocarcinomas...
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Veröffentlicht in: | Cancer letters 2004-10, Vol.214 (1), p.121-128 |
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Sprache: | eng |
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Zusammenfassung: | Caveolin-1 has been implicated in cellular transformation and tumorigenesis. We assessed lung cancer specimens for caveolin-1 expression immunohistochemistry. A majority of the cell types in the lung and the bronchial epithelium normally exhibited positive staining for caveolin-1. In adenocarcinomas (ADs) of positive staining for caveolin-1, pT1 tumors exhibited significantly higher staining than pT2–pT4 tumors (
P=0.0240). In squamous cell carcinomas (SCCs), pT1–pT2 tumors expressed significantly lower expression levels than pT3–pT4 tumors (
P=0.0175). In AD, loss of caveolin-1 may be essential for tumor extension and dedifferentiation. In contrast, caveolin-1 overexpression may be correlated with tumor extension in SCC. |
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ISSN: | 0304-3835 1872-7980 |
DOI: | 10.1016/j.canlet.2004.04.017 |