A sugar that benefits failing hearts

Abstract Ischemia is a major etiological factor in the development and progression of congestive heart failure. Current pharmaceutical treatments do not address the underlying metabolic problem within the heart. Adenosine triphosphate levels, critical for the preservation of cellular integrity, intr...

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Veröffentlicht in:	International journal of cardiology 2009-01, Vol.131 (3), p.398-398
Hauptverfasser:	St.Cyr, J.A, Schneider, Joseph R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - deficiency Administration, Oral Biological and medical sciences Cardiology. Vascular system Cardiovascular Congestive heart failure Energy Metabolism Heart Heart Failure - drug therapy Heart Failure - metabolism Heart failure, cardiogenic pulmonary edema, cardiac enlargement Humans Ischemia Medical sciences Ribose Ribose - administration & dosage
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Beschreibung
Zusammenfassung:	Abstract Ischemia is a major etiological factor in the development and progression of congestive heart failure. Current pharmaceutical treatments do not address the underlying metabolic problem within the heart. Adenosine triphosphate levels, critical for the preservation of cellular integrity, intracellular enzymatic reactions, and function, are depleted with myocardial ischemia, and in heart failure as well. Future therapies should look to enhance myocardial energy metabolism in the failing heart.
ISSN:	0167-5273 1874-1754
DOI:	10.1016/j.ijcard.2007.08.012