A concise total synthesis of (+)-okaramine C

A concise total synthesis of (+)-okaramine C

The first total synthesis of (+)-okaramine C is described. Our previously described selenocyclisation-oxidative deselenation sequence was used to establish a 3a-hydroxy-pyrrolo[2,3-b]indole core, which was modified by selective epimerisation to the common pyrrolo[2,3-b]indole of the okaramines.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic & biomolecular chemistry 2004-09, Vol.2 (17), p.2415-2417
Hauptverfasser: Hewitt, Peter R, Cleator, Ed, Ley, Steven V
Format: Artikel
Sprache:eng
Schlagworte:
Indole Alkaloids - chemical synthesis
Indole Alkaloids - chemistry
Molecular Conformation
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The first total synthesis of (+)-okaramine C is described. Our previously described selenocyclisation-oxidative deselenation sequence was used to establish a 3a-hydroxy-pyrrolo[2,3-b]indole core, which was modified by selective epimerisation to the common pyrrolo[2,3-b]indole of the okaramines.
ISSN:1477-0520
1477-0539
DOI:10.1039/b410180d